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CDC25B

GENERAL INFORMATION

Gene name

 CDC25B

Gene description

 Cell division cycle 25B

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in several tissue types, most abundant in the gastrointestinal tract and lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA038892 , HPA038893
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038892
HPA038893

GENE INFORMATION

Gene name

 CDC25B

Synonyms

Description

 Cell division cycle 25B (HGNC Symbol)

Entrez gene summary

 CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 3786772 - 3806121

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101224 (version 83.38)

Entrez gene

 994

UniProt

 P30305 (UniProt - Evidence at protein level)

neXtProt

 NX_P30305

Antibodypedia

 CDC25B antibodies

PROTEIN BROWSER
CDC25B-003
CDC25B-004
CDC25B-005
CDC25B-201
CDC25B-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC25B-003
ENSP00000405972
ENST00000439880
P30305 [Direct mapping]
M-phase inducer phosphatase 2
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000087 [mitotic M phase]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0008284 [positive regulation of cell proliferation]
GO:0019901 [protein kinase binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0051301 [cell division]
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 566 aa
63.4 kDa 		No 0
CDC25B-004
ENSP00000339170
ENST00000340833
P30305 [Direct mapping]
M-phase inducer phosphatase 2
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000087 [mitotic M phase]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0008284 [positive regulation of cell proliferation]
GO:0019901 [protein kinase binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0051301 [cell division]
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 539 aa
60.8 kDa 		No 0
CDC25B-005
ENSP00000245960
ENST00000245960
P30305 [Direct mapping]
M-phase inducer phosphatase 2
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000087 [mitotic M phase]
GO:0000278 [mitotic cell cycle]
GO:0000922 [spindle pole]
GO:0001556 [oocyte maturation]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006470 [protein dephosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0007144 [female meiosis I]
GO:0008284 [positive regulation of cell proliferation]
GO:0019901 [protein kinase binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0051301 [cell division]
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 580 aa
65 kDa 		No 0
CDC25B-201
ENSP00000339125
ENST00000344256
B4DIG0 [Direct mapping]
M-phase inducer phosphatase 2; cDNA FLJ53333, highly similar to M-phase inducer phosphatase 2 (EC 3.1.3.48)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000087 [mitotic M phase]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006470 [protein dephosphorylation]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
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 516 aa
58.9 kDa 		No 0
CDC25B-202
ENSP00000368918
ENST00000379598
G8JLH2 [Direct mapping]
M-phase inducer phosphatase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000087 [mitotic M phase]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006470 [protein dephosphorylation]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
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 489 aa
56 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.