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ARFRP1

GENERAL INFORMATION

Gene name

 ARFRP1

Gene description

 ADP-ribosylation factor related protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA047028
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047028

GENE INFORMATION

Gene name

 ARFRP1 (HGNC Symbol)

Synonyms

 ARL18, ARP, Arp1

Description

 ADP-ribosylation factor related protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 63698642 - 63708025

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101246 (version 83.38)

Entrez gene

 10139

UniProt

 Q13795 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13795

Antibodypedia

 ARFRP1 antibodies

PROTEIN BROWSER
ARFRP1-001
ARFRP1-005
ARFRP1-007
ARFRP1-010
ARFRP1-201
ARFRP1-202
ARFRP1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARFRP1-001
ENSP00000479616
ENST00000618838
Q13795 [Direct mapping]
ADP-ribosylation factor-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043001 [Golgi to plasma membrane protein transport]
Show all
 201 aa
22.6 kDa 		No 0
ARFRP1-005
ENSP00000479058
ENST00000612157
Q13795 [Direct mapping]
ADP-ribosylation factor-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043001 [Golgi to plasma membrane protein transport]
Show all
 173 aa
19.3 kDa 		No 0
ARFRP1-007
ENSP00000484109
ENST00000612256
Q13795 [Direct mapping]
ADP-ribosylation factor-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043001 [Golgi to plasma membrane protein transport]
Show all
 154 aa
17.1 kDa 		No 0
ARFRP1-010
ENSP00000476756
ENST00000607873
Q13795 [Direct mapping]
ADP-ribosylation factor-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043001 [Golgi to plasma membrane protein transport]
Show all
 154 aa
17.1 kDa 		No 0
ARFRP1-201
ENSP00000483130
ENST00000614942
Q13795 [Direct mapping]
ADP-ribosylation factor-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043001 [Golgi to plasma membrane protein transport]
Show all
 121 aa
13.8 kDa 		No 0
ARFRP1-202
ENSP00000479940
ENST00000619493
Q13795 [Direct mapping]
ADP-ribosylation factor-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043001 [Golgi to plasma membrane protein transport]
Show all
 201 aa
22.6 kDa 		No 0
ARFRP1-203
ENSP00000483486
ENST00000622789
Q13795 [Direct mapping]
ADP-ribosylation factor-related protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007369 [gastrulation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0034067 [protein localization to Golgi apparatus]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043001 [Golgi to plasma membrane protein transport]
Show all
 201 aa
22.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.