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TRIB3

GENERAL INFORMATION

Gene name

 TRIB3

Gene description

 Tribbles pseudokinase 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (thyroid gland)
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 TRIB3 (HGNC Symbol)

Synonyms

 C20orf97, dJ1103G7.3, TRB3

Description

 Tribbles pseudokinase 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 362835 - 397559

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101255 (version 83.38)

Entrez gene

 57761

UniProt

 Q96RU7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96RU7

Antibodypedia

 TRIB3 antibodies

PROTEIN BROWSER
TRIB3-001
TRIB3-002
TRIB3-003
TRIB3-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIB3-001
ENSP00000217233
ENST00000217233
Q96RU7 [Direct mapping]
Tribbles homolog 3
Show all
Enzymes
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0004672 [protein kinase activity]
GO:0004860 [protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010827 [regulation of glucose transport]
GO:0019901 [protein kinase binding]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032092 [positive regulation of protein binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043405 [regulation of MAP kinase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0055106 [ubiquitin-protein transferase regulator activity]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 358 aa
39.6 kDa 		No 0
TRIB3-002
ENSP00000415416
ENST00000422053
J3KR25 [Direct mapping]
Tribbles homolog 3
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003714 [transcription corepressor activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006468 [protein phosphorylation]
GO:0010827 [regulation of glucose transport]
GO:0019899 [enzyme binding]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031965 [nuclear membrane]
GO:0032092 [positive regulation of protein binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032869 [cellular response to insulin stimulus]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0055106 [ubiquitin-protein transferase regulator activity]
Show all
 385 aa
42.8 kDa 		No 0
TRIB3-003
ENSP00000391873
ENST00000449710
B0QYQ2 [Direct mapping]
Tribbles homolog 3
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
Show all
 271 aa
29.9 kDa 		No 0
TRIB3-004
ENSP00000478194
ENST00000615226
A0A087WTX3 [Direct mapping]
Tribbles homolog 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
Show all
 130 aa
14.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.