Fields »
ABOUT
HELP
BLOG
CSNK2A1

GENERAL INFORMATION

Gene name

 CSNK2A1

Gene description

 Casein kinase 2, alpha 1 polypeptide

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
CAB020680 , CAB069395
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB020680
CAB069395

GENE INFORMATION

Gene name

 CSNK2A1

Synonyms

Description

 Casein kinase 2, alpha 1 polypeptide (HGNC Symbol)

Entrez gene summary

 Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 473591 - 543821

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101266 (version 83.38)

Entrez gene

 1457

UniProt

 P68400 (UniProt - Evidence at protein level)

neXtProt

 NX_P68400

Antibodypedia

 CSNK2A1 antibodies

PROTEIN BROWSER
CSNK2A1-001
CSNK2A1-002
CSNK2A1-003
CSNK2A1-005
CSNK2A1-006
CSNK2A1-007
CSNK2A1-009
CSNK2A1-010
CSNK2A1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CSNK2A1-001
ENSP00000339247
ENST00000349736
P68400 [Direct mapping]
Casein kinase II subunit alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell proliferation]
GO:0016055 [Wnt signaling pathway]
GO:0016580 [Sin3 complex]
GO:0016581 [NuRD complex]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030307 [positive regulation of cell growth]
GO:0031519 [PcG protein complex]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045732 [positive regulation of protein catabolic process]
GO:0047485 [protein N-terminus binding]
GO:0048511 [rhythmic process]
GO:0051879 [Hsp90 protein binding]
GO:0061077 [chaperone-mediated protein folding]
GO:0071174 [mitotic spindle checkpoint]
Show all
 391 aa
45.1 kDa 		No 0
CSNK2A1-002
ENSP00000217244
ENST00000217244
P68400 [Direct mapping]
Casein kinase II subunit alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell proliferation]
GO:0016055 [Wnt signaling pathway]
GO:0016580 [Sin3 complex]
GO:0016581 [NuRD complex]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030307 [positive regulation of cell growth]
GO:0031519 [PcG protein complex]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045732 [positive regulation of protein catabolic process]
GO:0047485 [protein N-terminus binding]
GO:0048511 [rhythmic process]
GO:0051879 [Hsp90 protein binding]
GO:0061077 [chaperone-mediated protein folding]
GO:0071174 [mitotic spindle checkpoint]
Show all
 391 aa
45.1 kDa 		No 0
CSNK2A1-003
ENSP00000383076
ENST00000400217
P68400 [Direct mapping]
Casein kinase II subunit alpha
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell proliferation]
GO:0016055 [Wnt signaling pathway]
GO:0016580 [Sin3 complex]
GO:0016581 [NuRD complex]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030307 [positive regulation of cell growth]
GO:0031519 [PcG protein complex]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045732 [positive regulation of protein catabolic process]
GO:0047485 [protein N-terminus binding]
GO:0048511 [rhythmic process]
GO:0051879 [Hsp90 protein binding]
GO:0061077 [chaperone-mediated protein folding]
GO:0071174 [mitotic spindle checkpoint]
Show all
 255 aa
29.2 kDa 		No 0
CSNK2A1-005
ENSP00000476486
ENST00000608066
V9GY80 [Direct mapping]
Casein kinase II subunit alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 80 aa
9.5 kDa 		No 0
CSNK2A1-006
ENSP00000476547
ENST00000609525
V9GYA2 [Direct mapping]
Casein kinase II subunit alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 74 aa
8.7 kDa 		No 0
CSNK2A1-007
ENSP00000477147
ENST00000460062
V9GYW6 [Direct mapping]
Casein kinase II subunit alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 27 aa
3.2 kDa 		No 0
CSNK2A1-009
ENSP00000383086
ENST00000400227
E7EU96 [Direct mapping]
Casein kinase II subunit alpha
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 385 aa
45.3 kDa 		No 0
CSNK2A1-010
ENSP00000481572
ENST00000619801
A0A087WY74 [Direct mapping]
Casein kinase II subunit alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 118 aa
13.8 kDa 		No 0
CSNK2A1-201
ENSP00000479630
ENST00000619188
Q5U5J2 [Direct mapping]
CSNK2A1 protein; Casein kinase II subunit alpha
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 397 aa
45.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.