Expression of RSPO4 in cancer - Summary - The Human Protein Atlas

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RSPO4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RSPO4
Gene description	R-spondin 4
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BEWO, NTERA-2, SK-BR-3, U-2 OS)
HPA (normal tissue):	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA048887
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048887

GENE INFORMATION
Gene name	RSPO4 (HGNC Symbol)
Synonyms	C20orf182, dJ824F16.3
Description	R-spondin 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	958452 - 1002264
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101282 (version 83.38)
Entrez gene	343637
UniProt	Q2I0M5 (UniProt - Evidence at protein level)
neXtProt	NX_Q2I0M5
Antibodypedia	RSPO4 antibodies

PROTEIN BROWSER

RSPO4-001	RSPO4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RSPO4-001 ENSP00000217260 ENST00000217260	Q2I0M5 [Direct mapping] R-spondin-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0008201 [heparin binding] GO:0016055 [Wnt signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	234 aa 26.2 kDa	Yes	0
RSPO4-002 ENSP00000383475 ENST00000400634	Q2I0M5 [Direct mapping] R-spondin-4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0008201 [heparin binding] GO:0016055 [Wnt signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	172 aa 19.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.