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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CCM2L
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CCM2L

Gene description

Cerebral cavernous malformation 2-like

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (EFO-21, HUVEC TERT2, NTERA-2, SCLC-21H)
HPA (normal tissue):Tissue enriched (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

RNA data suggests expression in spleen

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Uncertain based on 1 antibody.
HPA008434
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA008434

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant tissues were in general negative.

GENE INFORMATION

Gene name

CCM2L (HGNC Symbol)

Synonyms

C20orf160, dJ310O13.5

Description

Cerebral cavernous malformation 2-like (HGNC Symbol)

Entrez gene summary

Chromosome

20

Cytoband

q11.21

Chromosome location (bp)

32010450 - 32032180

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101331 (version 83.38)

Entrez gene

140706

UniProt

Q9NUG4 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9NUG4

Antibodypedia

CCM2L antibodies

PROTEIN BROWSER

CCM2L-001
CCM2L-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCM2L-001
ENSP00000262659
ENST00000262659
Q9NUG4 [Direct mapping]
Cerebral cavernous malformations 2 protein-like
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003209 [cardiac atrium morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0008150 [biological_process]
GO:0032091 [negative regulation of protein binding]
GO:0034111 [negative regulation of homotypic cell-cell adhesion]
GO:0042060 [wound healing]
GO:0055017 [cardiac muscle tissue growth]
GO:0090271 [positive regulation of fibroblast growth factor production]
Show all
433 aa
46.7 kDa
No 0
CCM2L-003
ENSP00000392448
ENST00000452892
Q5JYR8 [Direct mapping]
Cerebral cavernous malformations 2 protein-like
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Predicted intracellular proteins
Show all
324 aa
35.2 kDa
No 0

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