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PLCB4

GENERAL INFORMATION

Gene name

 PLCB4

Gene description

 Phospholipase C, beta 4

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (colorectal cancer)
HPA (cell line):Cell line enhanced (LHCN-M2, RPTEC TERT1)
HPA (normal tissue):Tissue enhanced (thyroid gland)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PLCB4

Synonyms

Description

 Phospholipase C, beta 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]

Chromosome

 20

Cytoband

Chromosome location (bp)

 9068763 - 9481242

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101333 (version 83.38)

Entrez gene

 5332

UniProt

 Q15147 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15147

Antibodypedia

 PLCB4 antibodies

PROTEIN BROWSER
PLCB4-001
PLCB4-002
PLCB4-004
PLCB4-007
PLCB4-008
PLCB4-011
PLCB4-012
PLCB4-201
PLCB4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLCB4-001
ENSP00000367754
ENST00000378493
Q15147 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 1175 aa
134.5 kDa 		No 0
PLCB4-002
ENSP00000412982
ENST00000441846
B1AJW3 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
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 110 aa
12.4 kDa 		No 0
PLCB4-004
ENSP00000395753
ENST00000416836
B1AJW1 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
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 60 aa
7.2 kDa 		No 0
PLCB4-007
ENSP00000391614
ENST00000437503
B1AJW2 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
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 81 aa
9.4 kDa 		No 0
PLCB4-008
ENSP00000385805
ENST00000407043
B1AJW4 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
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 113 aa
12.8 kDa 		No 0
PLCB4-011
ENSP00000367762
ENST00000378501
Q15147 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0014069 [postsynaptic density]
GO:0016042 [lipid catabolic process]
GO:0030425 [dendrite]
GO:0035556 [intracellular signal transduction]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051019 [mitogen-activated protein kinase binding]
Show all
 1194 aa
136.1 kDa 		No 0
PLCB4-012
ENSP00000390616
ENST00000414679
Q15147 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 1187 aa
135.8 kDa 		No 0
PLCB4-201
ENSP00000278655
ENST00000278655
Q15147 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 1175 aa
134.5 kDa 		No 0
PLCB4-202
ENSP00000367734
ENST00000378473
Q15147 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 1187 aa
135.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.