Expression of TLDC2 in cancer - Summary - The Human Protein Atlas

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TLDC2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TLDC2
Gene description	TBC/LysM-associated domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (colorectal cancer)
HPA (cell line):	Cell line enriched (HMC-1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA047468
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047468

GENE INFORMATION
Gene name	TLDC2 (HGNC Symbol)
Synonyms	C20orf118, dJ132F21.2
Description	TBC/LysM-associated domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q11.23
Chromosome location (bp)	36876121 - 36894235
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101342 (version 83.38)
Entrez gene	140711
UniProt	A0PJX2 (UniProt - Evidence at transcript level)
neXtProt	NX_A0PJX2
Antibodypedia	TLDC2 antibodies

PROTEIN BROWSER

TLDC2-001	TLDC2-003	TLDC2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TLDC2-001 ENSP00000394804 ENST00000436941	A2A2J3 [Direct mapping] TLD domain-containing protein 2 Show all	Predicted intracellular proteins Show all		27 aa 3 kDa	No	0
TLDC2-003 ENSP00000217320 ENST00000217320	A0PJX2 [Direct mapping] TLD domain-containing protein 2 Show all	Predicted intracellular proteins Show all		215 aa 23.9 kDa	No	0
TLDC2-004 ENSP00000473323 ENST00000602922	A0PJX2 [Direct mapping] TLD domain-containing protein 2 Show all	Predicted intracellular proteins Show all		215 aa 23.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.