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PAK7

GENERAL INFORMATION

Gene name

 PAK7

Gene description

 P21 protein (Cdc42/Rac)-activated kinase 7

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA020444
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020444

GENE INFORMATION

Gene name

 PAK7 (HGNC Symbol)

Synonyms

 KIAA1264, PAK5

Description

 P21 protein (Cdc42/Rac)-activated kinase 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p12.2

Chromosome location (bp)

 9537389 - 9839041

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101349 (version 83.38)

Entrez gene

 57144

UniProt

 Q9P286 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P286

Antibodypedia

 PAK7 antibodies

PROTEIN BROWSER
PAK7-001
PAK7-002
PAK7-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAK7-001
ENSP00000367686
ENST00000378429
Q9P286 [Direct mapping]
Serine/threonine-protein kinase PAK 7
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0007626 [locomotory behavior]
GO:0008283 [cell proliferation]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
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 719 aa
80.7 kDa 		No 0
PAK7-002
ENSP00000322957
ENST00000353224
Q9P286 [Direct mapping]
Serine/threonine-protein kinase PAK 7
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008283 [cell proliferation]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 719 aa
80.7 kDa 		No 0
PAK7-003
ENSP00000367679
ENST00000378423
Q9P286 [Direct mapping]
Serine/threonine-protein kinase PAK 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007010 [cytoskeleton organization]
GO:0007165 [signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008283 [cell proliferation]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 719 aa
80.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.