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Cytoplasmic and membrane expression in several tissues.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images. Antibody staining in parathyroid gland is not annotated, view images.
A majority of cancer tissues showed weak to moderate cytoplasmic staining. Strong immunoreactivity was found in some pancreatic and liver cancers.
GENE INFORMATION
Gene name
KIF3B (HGNC Symbol)
Synonyms
FLA8, KIAA0359, KLP-11
Description
Kinesin family member 3B (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]