Cell atlas - IDH3B - The Human Protein Atlas

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IDH3B

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	IDH3B
Gene description	Isocitrate dehydrogenase 3 (NAD+) beta
Protein class	Citric acid cycle related proteins Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (validated)
Mouse	Localized to the Mitochondria in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA049387 , HPA054180
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049387	A549	Mitochondria
	HPA049387	U-2 OS	Mitochondria
	HPA054180	A549	Mitochondria
	HPA054180	U-2 OS	Mitochondria

MOUSE CELLS

Main location

Mitochondria

Mouse gene

ENSMUSG00000027406 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA049387	NIH 3T3	Mitochondria

GENE INFORMATION
Gene name	IDH3B (HGNC Symbol)
Synonyms	RP46
Description	Isocitrate dehydrogenase 3 (NAD+) beta (HGNC Symbol)
Entrez gene summary	Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	2658395 - 2664219
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101365 (version 83.38)
Entrez gene	3420
UniProt	O43837 (UniProt - Evidence at protein level)
neXtProt	NX_O43837
Antibodypedia	IDH3B antibodies

PROTEIN BROWSER

IDH3B-001	IDH3B-010	IDH3B-011	IDH3B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IDH3B-001 ENSP00000482773 ENST00000474315	A0A087WZN1 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004449 [isocitrate dehydrogenase (NAD+) activity] GO:0005739 [mitochondrion] GO:0006099 [tricarboxylic acid cycle] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	387 aa 42.4 kDa	No	0
IDH3B-010 ENSP00000370232 ENST00000380851	O43837 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004449 [isocitrate dehydrogenase (NAD+) activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006099 [tricarboxylic acid cycle] GO:0009055 [electron carrier activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	383 aa 41.9 kDa	No	0
IDH3B-011 ENSP00000370223 ENST00000380843	O43837 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004449 [isocitrate dehydrogenase (NAD+) activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006099 [tricarboxylic acid cycle] GO:0006102 [isocitrate metabolic process] GO:0006103 [2-oxoglutarate metabolic process] GO:0006734 [NADH metabolic process] GO:0009055 [electron carrier activity] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	385 aa 42.2 kDa	No	0
IDH3B-201 ENSP00000484922 ENST00000613370	A0A087X2E5 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004449 [isocitrate dehydrogenase (NAD+) activity] GO:0005739 [mitochondrion] GO:0006099 [tricarboxylic acid cycle] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	376 aa 41.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.