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A majority of the malignant cells displayed moderate nuclear/nucleolar immunoreactivity with an additional cytoplasmic staining in some cases. Most lymphomas, along with several cases of melanomas, squamous cell carcinomas, colorectal, liver and endometrial cancers showed strong staining.
GENE INFORMATION
Gene name
E2F1 (HGNC Symbol)
Synonyms
RBBP3, RBP3
Description
E2F transcription factor 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000077 [DNA damage checkpoint] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000278 [mitotic cell cycle] GO:0000790 [nuclear chromatin] GO:0001047 [core promoter binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007219 [Notch signaling pathway] GO:0007283 [spermatogenesis] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010628 [positive regulation of gene expression] GO:0012501 [programmed cell death] GO:0019901 [protein kinase binding] GO:0030900 [forebrain development] GO:0035189 [Rb-E2F complex] GO:0043276 [anoikis] GO:0043392 [negative regulation of DNA binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045599 [negative regulation of fat cell differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048255 [mRNA stabilization] GO:0051726 [regulation of cell cycle] GO:0070345 [negative regulation of fat cell proliferation] GO:0071398 [cellular response to fatty acid] GO:0071456 [cellular response to hypoxia] GO:0071466 [cellular response to xenobiotic stimulus] GO:0071930 [negative regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1990086 [lens fiber cell apoptotic process] GO:1990090 [cellular response to nerve growth factor stimulus] GO:2000045 [regulation of G1/S transition of mitotic cell cycle]