Cell atlas - PXMP4 - The Human Protein Atlas

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PXMP4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Peroxisomes

Human cell
	Nucleoli
	Vesicles

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GENERAL INFORMATION
Gene name	PXMP4
Gene description	Peroxisomal membrane protein 4, 24kDa
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the peroxisome. In addition localized to the nucleoli (fibrillar center).
RNA cell category	Cell line enhanced (T-47d, SK-BR-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Peroxisomes (approved)
Additional location	In addition localized to the Nucleoli fibrillar center (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA050077
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, SK-BR-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the peroxisome. In addition localized to the nucleoli (fibrillar center).

Main location

Peroxisomes (approved)

Additional location

Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA050077	CACO-2	Nucleoli fibrillar center
	HPA050077	CACO-2	Peroxisomes
	HPA050077	MCF7	Peroxisomes

CUSTOM DATA


	Toggle channels

Thumbnail	Antibody	Cell line	Assay	Description
	HPA050077	U-2 OS	Image	PXMP4 localizes to peroxisomes, as it co-localizes with the peroxisomal marker ABCD3.

GENE INFORMATION
Gene name	PXMP4 (HGNC Symbol)
Synonyms	PMP24
Description	Peroxisomal membrane protein 4, 24kDa (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q11.22
Chromosome location (bp)	33702754 - 33720319
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101417 (version 83.38)
Entrez gene	11264
UniProt	Q9Y6I8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6I8
Antibodypedia	PXMP4 antibodies

PROTEIN BROWSER

PXMP4-001	PXMP4-002	PXMP4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PXMP4-001 ENSP00000386385 ENST00000409299	Q9Y6I8 [Direct mapping] Peroxisomal membrane protein 4 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] Show all	212 aa 24.3 kDa	No	2
PXMP4-002 ENSP00000343071 ENST00000344022	Q9Y6I8 [Direct mapping] Peroxisomal membrane protein 4 Show all	Transporters Transporter channels and pores Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] Show all	71 aa 7.8 kDa	No	0
PXMP4-003 ENSP00000217398 ENST00000217398	B4DWH1 [Direct mapping] Peroxisomal membrane protein 4; cDNA FLJ53748, moderately similar to Peroxisomal membrane protein 4 Show all	Predicted intracellular proteins Show all		144 aa 15.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.