Expression of ASIP in cancer - Summary - The Human Protein Atlas

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ASIP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ASIP
Gene description	Agouti signaling protein
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CACO-2)
HPA (normal tissue):	Group enriched (epididymis, ovary, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA048636
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048636

GENE INFORMATION
Gene name	ASIP (HGNC Symbol)
Synonyms	AGTIL, ASP
Description	Agouti signaling protein (HGNC Symbol)
Entrez gene summary	In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q11.22
Chromosome location (bp)	34194569 - 34269344
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101440 (version 83.38)
Entrez gene	434
UniProt	P42127 (UniProt - Evidence at protein level)
neXtProt	NX_P42127
Antibodypedia	ASIP antibodies

PROTEIN BROWSER

ASIP-001	ASIP-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASIP-001 ENSP00000364092 ENST00000374954	P42127 [Direct mapping] Agouti-signaling protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005102 [receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0009755 [hormone-mediated signaling pathway] Show all	132 aa 14.5 kDa	Yes	0
ASIP-002 ENSP00000454804 ENST00000568305	P42127 [Direct mapping] Agouti-signaling protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005102 [receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0009755 [hormone-mediated signaling pathway] GO:0048023 [positive regulation of melanin biosynthetic process] Show all	132 aa 14.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.