Expression of CST4 in cancer - Summary - The Human Protein Atlas

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CST4

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CST4
Gene description	Cystatin S
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CACO-2, RT4, TIME)
HPA (normal tissue):	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of cells in salivary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA043706 , HPA044763
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable) and urothelial cancer (favourable).
Ovarian cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043706	HPA044763

GENE INFORMATION
Gene name	CST4
Synonyms
Description	Cystatin S (HGNC Symbol)
Entrez gene summary	The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but antibacterial and antiviral activity is present, consistent with a protective function. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p11.21
Chromosome location (bp)	23685640 - 23689040
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101441 (version 83.38)
Entrez gene	1472
UniProt	P01036 (UniProt - Evidence at protein level)
neXtProt	NX_P01036
Antibodypedia	CST4 antibodies

PROTEIN BROWSER

CST4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CST4-001 ENSP00000217423 ENST00000217423	P01036 [Direct mapping] Cystatin-S Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste] GO:0001895 [retina homeostasis] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] GO:0045861 [negative regulation of proteolysis] GO:0070062 [extracellular exosome] Show all	141 aa 16.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.