Expression of WFDC2 in cancer - Summary - The Human Protein Atlas

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WFDC2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	WFDC2
Gene description	WAP four-disulfide core domain 2
Protein class	Cancer-related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (A-431, CAPAN-2, EFO-21, HaCaT, RPTEC TERT1)
HPA (normal tissue):	Tissue enriched (cervix, uterine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 1 antibody. HPA042302
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and glioma (unfavourable).
Renal cancer p<0.001 Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042302

GENE INFORMATION
Gene name	WFDC2 (HGNC Symbol)
Synonyms	dJ461P17.6, EDDM4, HE4, WAP5
Description	WAP four-disulfide core domain 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	45469706 - 45481532
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101443 (version 83.38)
Entrez gene	10406
UniProt	Q14508 (UniProt - Evidence at protein level)
neXtProt	NX_Q14508
Antibodypedia	WFDC2 antibodies

PROTEIN BROWSER

WFDC2-002	WFDC2-003	WFDC2-005	WFDC2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WFDC2-002 ENSP00000361761 ENST00000372676	Q14508 [Direct mapping] WAP four-disulfide core domain protein 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007283 [spermatogenesis] GO:0010951 [negative regulation of endopeptidase activity] GO:0019828 [aspartic-type endopeptidase inhibitor activity] GO:0030414 [peptidase inhibitor activity] GO:0070062 [extracellular exosome] Show all	124 aa 13 kDa	Yes	0
WFDC2-003 ENSP00000217425 ENST00000217425	Q14508 [Direct mapping] WAP four-disulfide core domain protein 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007283 [spermatogenesis] GO:0010951 [negative regulation of endopeptidase activity] GO:0019828 [aspartic-type endopeptidase inhibitor activity] GO:0030414 [peptidase inhibitor activity] GO:0070062 [extracellular exosome] Show all	102 aa 11 kDa	Yes	0
WFDC2-005 ENSP00000340215 ENST00000339946	Q14508 [Direct mapping] WAP four-disulfide core domain protein 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007283 [spermatogenesis] GO:0010951 [negative regulation of endopeptidase activity] GO:0019828 [aspartic-type endopeptidase inhibitor activity] GO:0030414 [peptidase inhibitor activity] GO:0070062 [extracellular exosome] Show all	76 aa 8.1 kDa	Yes	0
WFDC2-006 ENSP00000342890 ENST00000342873	Q14508 [Direct mapping] WAP four-disulfide core domain protein 2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007283 [spermatogenesis] GO:0010951 [negative regulation of endopeptidase activity] GO:0019828 [aspartic-type endopeptidase inhibitor activity] GO:0030414 [peptidase inhibitor activity] GO:0070062 [extracellular exosome] Show all	73 aa 8.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.