Fields »
ABOUT
HELP
BLOG
PPP1R16B

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 PPP1R16B

Gene description

 Protein phosphatase 1, regulatory subunit 16B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane. In addition localized to the nuclear speckles.

RNA cell category

 Cell line enhanced (U-266/70, HMC-1, Daudi)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (supported)

Additional location

 In addition localized to the Nuclear speckles (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA049571
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70, HMC-1, Daudi)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane. In addition localized to the nuclear speckles.

Main location

 Plasma membrane (supported)

Additional location

 Nuclear speckles (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA049571 A549 Nuclear speckles
Plasma membrane
HPA049571 SH-SY5Y Nuclear speckles
Plasma membrane
HPA049571 U-2 OS Nuclear speckles
Plasma membrane

GENE INFORMATION

Gene name

 PPP1R16B (HGNC Symbol)

Synonyms

 ANKRD4, KIAA0823, TIMAP

Description

 Protein phosphatase 1, regulatory subunit 16B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

Chromosome

 20

Cytoband

 q11.23

Chromosome location (bp)

 38805705 - 38923024

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101445 (version 83.38)

Entrez gene

 26051

UniProt

 Q96T49 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96T49

Antibodypedia

 PPP1R16B antibodies

PROTEIN BROWSER
PPP1R16B-001
PPP1R16B-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP1R16B-001
ENSP00000299824
ENST00000299824
Q96T49 [Direct mapping]
Protein phosphatase 1 regulatory inhibitor subunit 16B
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0035308 [negative regulation of protein dephosphorylation]
GO:0042995 [cell projection]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050790 [regulation of catalytic activity]
GO:0051489 [regulation of filopodium assembly]
GO:0061028 [establishment of endothelial barrier]
GO:1902309 [negative regulation of peptidyl-serine dephosphorylation]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
Show all
 567 aa
63.6 kDa 		No 0
PPP1R16B-004
ENSP00000362428
ENST00000373331
Q96T49 [Direct mapping]
Protein phosphatase 1 regulatory inhibitor subunit 16B
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0008599 [protein phosphatase type 1 regulator activity]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0035308 [negative regulation of protein dephosphorylation]
GO:0042995 [cell projection]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050790 [regulation of catalytic activity]
GO:0051489 [regulation of filopodium assembly]
GO:0061028 [establishment of endothelial barrier]
GO:1902309 [negative regulation of peptidyl-serine dephosphorylation]
GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis]
Show all
 525 aa
58.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.