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FAM83D

GENERAL INFORMATION

Gene name

 FAM83D

Gene description

 Family with sequence similarity 83, member D

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (esophagus, smooth muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA049333
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), pancreatic cancer (unfavourable), endometrial cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Pancreatic cancer p<0.001
Endometrial cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049333

GENE INFORMATION

Gene name

 FAM83D (HGNC Symbol)

Synonyms

 C20orf129, dJ616B8.3

Description

 Family with sequence similarity 83, member D (HGNC Symbol)

Entrez gene summary

Chromosome

 20

Cytoband

 q11.23

Chromosome location (bp)

 38926312 - 38953106

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101447 (version 83.38)

Entrez gene

 81610

UniProt

 Q9H4H8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H4H8

Antibodypedia

 FAM83D antibodies

PROTEIN BROWSER
FAM83D-001
FAM83D-002
FAM83D-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FAM83D-001
ENSP00000481110
ENST00000619304
A0A087WXK8 [Direct mapping]
Chromosome 20 open reading frame 129; Protein FAM83D
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 615 aa
67.7 kDa 		No 0
FAM83D-002
ENSP00000481465
ENST00000619850
Q9H4H8 [Direct mapping]
Protein FAM83D
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001837 [epithelial to mesenchymal transition]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0008017 [microtubule binding]
GO:0008283 [cell proliferation]
GO:0016477 [cell migration]
GO:0019894 [kinesin binding]
GO:0019901 [protein kinase binding]
GO:0032006 [regulation of TOR signaling]
GO:0042176 [regulation of protein catabolic process]
GO:0051301 [cell division]
GO:0051310 [metaphase plate congression]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0097431 [mitotic spindle pole]
GO:1902480 [protein localization to mitotic spindle]
GO:1902808 [positive regulation of cell cycle G1/S phase transition]
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 585 aa
64.4 kDa 		No 0
FAM83D-201
ENSP00000217429
ENST00000217429
A0A087WXK8 [Direct mapping]
Chromosome 20 open reading frame 129; Protein FAM83D
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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 615 aa
67.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.