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PIGU

GENERAL INFORMATION

Gene name

 PIGU

Gene description

 Phosphatidylinositol glycan anchor biosynthesis, class U

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA041706 , HPA046766
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041706
HPA046766

GENE INFORMATION

Gene name

 PIGU (HGNC Symbol)

Synonyms

 bA346K17.2, CDC91L1, GAB1

Description

 Phosphatidylinositol glycan anchor biosynthesis, class U (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q11.22

Chromosome location (bp)

 34560542 - 34698790

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101464 (version 83.38)

Entrez gene

 128869

UniProt

 Q9H490 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H490

Antibodypedia

 PIGU antibodies

PROTEIN BROWSER
PIGU-001
PIGU-004
PIGU-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIGU-001
ENSP00000217446
ENST00000217446
Q9H490 [Direct mapping]
Phosphatidylinositol glycan anchor biosynthesis class U protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003923 [GPI-anchor transamidase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006501 [C-terminal protein lipidation]
GO:0006506 [GPI anchor biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016255 [attachment of GPI anchor to protein]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0034235 [GPI anchor binding]
GO:0042765 [GPI-anchor transamidase complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046425 [regulation of JAK-STAT cascade]
Show all
 435 aa
50.1 kDa 		Yes >9
PIGU-004
ENSP00000395755
ENST00000438215
Q5JWU1 [Direct mapping]
Phosphatidylinositol glycan anchor biosynthesis class U protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006506 [GPI anchor biosynthetic process]
GO:0016021 [integral component of membrane]
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 170 aa
19.7 kDa 		No 5
PIGU-201
ENSP00000363953
ENST00000374820
Q9H490 [Direct mapping]
Phosphatidylinositol glycan anchor biosynthesis class U protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003923 [GPI-anchor transamidase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006501 [C-terminal protein lipidation]
GO:0006506 [GPI anchor biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016255 [attachment of GPI anchor to protein]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0034235 [GPI anchor binding]
GO:0042765 [GPI-anchor transamidase complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046425 [regulation of JAK-STAT cascade]
Show all
 415 aa
47.6 kDa 		Yes >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.