Expression of TNNC2 in cancer - Summary - The Human Protein Atlas

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TNNC2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TNNC2
Gene description	Troponin C type 2 (fast)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (Hep G2, SCLC-21H)
HPA (normal tissue):	Tissue enriched (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in a subset of skeletal myocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA043174 , HPA058481
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043174	HPA058481

GENE INFORMATION
Gene name	TNNC2
Synonyms
Description	Troponin C type 2 (fast) (HGNC Symbol)
Entrez gene summary	Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	45823214 - 45833745
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101470 (version 83.38)
Entrez gene	7125
UniProt	P02585 (UniProt - Evidence at protein level)
neXtProt	NX_P02585
Antibodypedia	TNNC2 antibodies

PROTEIN BROWSER

TNNC2-001	TNNC2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNNC2-001 ENSP00000361638 ENST00000372557	C9J7T9 [Direct mapping] Troponin C type 2 (Fast), isoform CRA_a; Troponin C, skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	145 aa 16.4 kDa	No	0
TNNC2-003 ENSP00000361636 ENST00000372555	P02585 [Direct mapping] Troponin C, skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0003779 [actin binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005861 [troponin complex] GO:0006937 [regulation of muscle contraction] GO:0030049 [muscle filament sliding] Show all	160 aa 18.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.