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ACOT8

GENERAL INFORMATION

Gene name

 ACOT8

Gene description

 Acyl-CoA thioesterase 8

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression, sometimes in a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB010261
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB010261

GENE INFORMATION

Gene name

 ACOT8 (HGNC Symbol)

Synonyms

 hACTE-III, hTE, NAP1, PTE-2, PTE1

Description

 Acyl-CoA thioesterase 8 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]

Chromosome

 20

Cytoband

 q13.12

Chromosome location (bp)

 45841721 - 45857406

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101473 (version 83.38)

Entrez gene

 10005

UniProt

 O14734 (UniProt - Evidence at protein level)

neXtProt

 NX_O14734

Antibodypedia

 ACOT8 antibodies

PROTEIN BROWSER
ACOT8-001
ACOT8-003
ACOT8-004
ACOT8-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACOT8-001
ENSP00000217455
ENST00000217455
O14734 [Direct mapping]
Acyl-coenzyme A thioesterase 8
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006637 [acyl-CoA metabolic process]
GO:0006699 [bile acid biosynthetic process]
GO:0008206 [bile acid metabolic process]
GO:0016032 [viral process]
GO:0016290 [palmitoyl-CoA hydrolase activity]
GO:0016559 [peroxisome fission]
GO:0019432 [triglyceride biosynthetic process]
GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase]
GO:0033559 [unsaturated fatty acid metabolic process]
GO:0033882 [choloyl-CoA hydrolase activity]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0036109 [alpha-linolenic acid metabolic process]
GO:0043649 [dicarboxylic acid catabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047617 [acyl-CoA hydrolase activity]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0052815 [medium-chain acyl-CoA hydrolase activity]
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 319 aa
35.9 kDa 		No 0
ACOT8-003
ENSP00000416217
ENST00000426915
Q9BR14 [Direct mapping]
Acyl-coenzyme A thioesterase 8
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006637 [acyl-CoA metabolic process]
GO:0047617 [acyl-CoA hydrolase activity]
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 92 aa
9.9 kDa 		No 0
ACOT8-004
ENSP00000403862
ENST00000457981
H0Y698 [Direct mapping]
Acyl-coenzyme A thioesterase 8
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006637 [acyl-CoA metabolic process]
GO:0047617 [acyl-CoA hydrolase activity]
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 74 aa
8.3 kDa 		No 0
ACOT8-008
ENSP00000419403
ENST00000487205
H7C5A7 [Direct mapping]
Acyl-coenzyme A thioesterase 8
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006637 [acyl-CoA metabolic process]
GO:0047617 [acyl-CoA hydrolase activity]
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 209 aa
23.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.