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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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VAPA
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

VAPA

Gene description

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

Protein class

Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA009174
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA009174

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant cells showed moderate to strong cytoplasmic immunoreactivity. Strongest staining was observed in cervical and urothelial cancers.

GENE INFORMATION

Gene name

VAPA (HGNC Symbol)

Synonyms

hVAP-33, VAP-A

Description

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

18

Cytoband

p11.22

Chromosome location (bp)

9914002 - 9960021

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000101558 (version 83.38)

Entrez gene

9218

UniProt

Q9P0L0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9P0L0

Antibodypedia

VAPA antibodies

PROTEIN BROWSER

VAPA-001
VAPA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VAPA-001
ENSP00000382880
ENST00000400000
Q9P0L0 [Direct mapping]
Vesicle-associated membrane protein-associated protein A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0006665 [sphingolipid metabolic process]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007165 [signal transduction]
GO:0008017 [microtubule binding]
GO:0008219 [cell death]
GO:0016021 [integral component of membrane]
GO:0019904 [protein domain specific binding]
GO:0030148 [sphingolipid biosynthetic process]
GO:0031175 [neuron projection development]
GO:0031982 [vesicle]
GO:0033149 [FFAT motif binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0044281 [small molecule metabolic process]
GO:0044791 [positive regulation by host of viral release from host cell]
GO:0044828 [negative regulation by host of viral genome replication]
GO:0044829 [positive regulation by host of viral genome replication]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061025 [membrane fusion]
GO:0070972 [protein localization to endoplasmic reticulum]
GO:0090114 [COPII-coated vesicle budding]
Show all
249 aa
27.9 kDa
No 1
VAPA-002
ENSP00000345656
ENST00000340541
Q9P0L0 [Direct mapping]
Vesicle-associated membrane protein-associated protein A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0006665 [sphingolipid metabolic process]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007165 [signal transduction]
GO:0008017 [microtubule binding]
GO:0008219 [cell death]
GO:0015630 [microtubule cytoskeleton]
GO:0016021 [integral component of membrane]
GO:0019904 [protein domain specific binding]
GO:0030148 [sphingolipid biosynthetic process]
GO:0031175 [neuron projection development]
GO:0031982 [vesicle]
GO:0033149 [FFAT motif binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0044281 [small molecule metabolic process]
GO:0044791 [positive regulation by host of viral release from host cell]
GO:0044828 [negative regulation by host of viral genome replication]
GO:0044829 [positive regulation by host of viral genome replication]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061025 [membrane fusion]
GO:0070972 [protein localization to endoplasmic reticulum]
GO:0090114 [COPII-coated vesicle budding]
Show all
294 aa
32.6 kDa
No 1

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