Expression of LPIN2 in cancer - Summary

GENERAL INFORMATION
Gene name	LPIN2
Gene description	Lipin 2
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types, high expression in liver and gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA017857 , HPA030550 , CAB015223
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA017857	HPA030550	CAB015223

GENE INFORMATION
Gene name	LPIN2 (HGNC Symbol)
Synonyms	KIAA0249
Description	Lipin 2 (HGNC Symbol)
Entrez gene summary	Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	p11.31
Chromosome location (bp)	2916994 - 3013315
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101577 (version 83.38)
Entrez gene	9663
UniProt	Q92539 (UniProt - Evidence at protein level)
neXtProt	NX_Q92539
Antibodypedia	LPIN2 antibodies

PROTEIN BROWSER

LPIN2-001	LPIN2-002	LPIN2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LPIN2-001 ENSP00000261596 ENST00000261596	Q92539 [Direct mapping] Phosphatidate phosphatase LPIN2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0008195 [phosphatidate phosphatase activity] GO:0009062 [fatty acid catabolic process] GO:0016311 [dephosphorylation] GO:0019432 [triglyceride biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046474 [glycerophospholipid biosynthetic process] Show all	896 aa 99.4 kDa	No	0
LPIN2-002 ENSP00000463026 ENST00000584294	J3KTK1 [Direct mapping] Phosphatidate phosphatase LPIN2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0008195 [phosphatidate phosphatase activity] GO:0009062 [fatty acid catabolic process] GO:0016311 [dephosphorylation] GO:0019432 [triglyceride biosynthetic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	233 aa 25.6 kDa	No	0
LPIN2-003 ENSP00000463810 ENST00000584915	J3QQN0 [Direct mapping] Phosphatidate phosphatase LPIN2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0008195 [phosphatidate phosphatase activity] GO:0009062 [fatty acid catabolic process] GO:0016311 [dephosphorylation] GO:0019432 [triglyceride biosynthetic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	129 aa 14.3 kDa	No	0