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MYL12A

GENERAL INFORMATION

Gene name

 MYL12A

Gene description

 Myosin, light chain 12A, regulatory, non-sarcomeric

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in myocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 4 antibodies.
HPA039262 , HPA045244 , HPA059197 , CAB004503
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MYL12A (HGNC Symbol)

Synonyms

 MLCB, MRCL3, MRLC3, MYL2B

Description

 Myosin, light chain 12A, regulatory, non-sarcomeric (HGNC Symbol)

Entrez gene summary

 This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]

Chromosome

 18

Cytoband

 p11.31

Chromosome location (bp)

 3247481 - 3256236

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101608 (version 83.38)

Entrez gene

 10627

UniProt

 P19105 (UniProt - Evidence at protein level)

neXtProt

 NX_P19105

Antibodypedia

 MYL12A antibodies

PROTEIN BROWSER
MYL12A-001
MYL12A-002
MYL12A-003
MYL12A-004
MYL12A-005
MYL12A-008
MYL12A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYL12A-001
ENSP00000217652
ENST00000217652
P19105 [Direct mapping]
Myosin regulatory light chain 12A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007411 [axon guidance]
GO:0016459 [myosin complex]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
Show all
 171 aa
19.8 kDa 		No 0
MYL12A-002
ENSP00000462171
ENST00000579226
P19105 [Direct mapping]
Myosin regulatory light chain 12A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007411 [axon guidance]
GO:0016459 [myosin complex]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
Show all
 171 aa
19.8 kDa 		No 0
MYL12A-003
ENSP00000462865
ENST00000583449
J3KT92 [Direct mapping]
Myosin regulatory light chain 12A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 12 aa
1.4 kDa 		No 0
MYL12A-004
ENSP00000463614
ENST00000578611
P19105 [Direct mapping]
Myosin regulatory light chain 12A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007411 [axon guidance]
GO:0016459 [myosin complex]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
Show all
 171 aa
19.8 kDa 		No 0
MYL12A-005
ENSP00000464359
ENST00000580887
J3QRS3 [Direct mapping]
Myosin regulatory light chain 12A; Myosin regulatory light chain MRCL3, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0008360 [regulation of cell shape]
GO:0016460 [myosin II complex]
GO:0030018 [Z disc]
GO:0035254 [glutamate receptor binding]
GO:0043234 [protein complex]
GO:0072661 [protein targeting to plasma membrane]
Show all
 177 aa
20.5 kDa 		No 0
MYL12A-008
ENSP00000463009
ENST00000578562
J3KTJ1 [Direct mapping]
Myosin regulatory light chain 12A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
Show all
 114 aa
13.1 kDa 		No 0
MYL12A-201
ENSP00000441231
ENST00000536605
P19105 [Direct mapping]
Myosin regulatory light chain 12A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007411 [axon guidance]
GO:0016459 [myosin complex]
GO:0048013 [ephrin receptor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
Show all
 171 aa
19.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.