Expression of CEP76 in cancer - Summary - The Human Protein Atlas

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CEP76

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CEP76
Gene description	Centrosomal protein 76kDa
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA039395
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039395

GENE INFORMATION
Gene name	CEP76 (HGNC Symbol)
Synonyms	C18orf9, FLJ12542, HsT1705
Description	Centrosomal protein 76kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Chromosome	18
Cytoband	p11.21
Chromosome location (bp)	12661833 - 12702777
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101624 (version 83.38)
Entrez gene	79959
UniProt	Q8TAP6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TAP6
Antibodypedia	CEP76 antibodies

PROTEIN BROWSER

CEP76-001	CEP76-003	CEP76-010	CEP76-011	CEP76-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEP76-001 ENSP00000262127 ENST00000262127	Q8TAP6 [Direct mapping] Centrosomal protein of 76 kDa Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0043234 [protein complex] GO:0046599 [regulation of centriole replication] Show all	659 aa 74.4 kDa	No	0
CEP76-003 ENSP00000403074 ENST00000423709	Q8TAP6 [Direct mapping] Centrosomal protein of 76 kDa Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0006996 [organelle organization] GO:0043234 [protein complex] GO:0046599 [regulation of centriole replication] Show all	584 aa 65.7 kDa	No	0
CEP76-010 ENSP00000467224 ENST00000585751	K7EP44 [Direct mapping] Centrosomal protein of 76 kDa Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		191 aa 21.8 kDa	No	0
CEP76-011 ENSP00000467361 ENST00000591034	K7EPF5 [Direct mapping] Centrosomal protein of 76 kDa Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		101 aa 11.6 kDa	No	0
CEP76-012 ENSP00000464911 ENST00000587666	K7EIV8 [Direct mapping] Centrosomal protein of 76 kDa Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		178 aa 19.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.