Expression of ST8SIA5 in cancer - Summary - The Human Protein Atlas

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ST8SIA5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ST8SIA5
Gene description	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enriched (WM-115)
HPA (normal tissue):	Tissue enhanced (adrenal gland, cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in CNS and adrenal gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA043813 , HPA046771
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043813	HPA046771

GENE INFORMATION
Gene name	ST8SIA5 (HGNC Symbol)
Synonyms	SIAT8E
Description	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The encoded protein, which is a member of glycosyltransferase family 29, may be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	q21.1
Chromosome location (bp)	46667821 - 46759257
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101638 (version 83.38)
Entrez gene	29906
UniProt	O15466 (UniProt - Evidence at protein level)
neXtProt	NX_O15466
Antibodypedia	ST8SIA5 antibodies

PROTEIN BROWSER

ST8SIA5-001	ST8SIA5-002	ST8SIA5-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ST8SIA5-001 ENSP00000321343 ENST00000315087	O15466 [Direct mapping] Alpha-2,8-sialyltransferase 8E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006688 [glycosphingolipid biosynthetic process] GO:0008373 [sialyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030173 [integral component of Golgi membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097503 [sialylation] Show all	376 aa 43.9 kDa	No	2
ST8SIA5-002 ENSP00000443683 ENST00000536490	F5H8D1 [Direct mapping] Alpha-2,8-sialyltransferase 8E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0006486 [protein glycosylation] GO:0008373 [sialyltransferase activity] GO:0030173 [integral component of Golgi membrane] GO:0097503 [sialylation] Show all	345 aa 40.1 kDa	No	2
ST8SIA5-004 ENSP00000445492 ENST00000538168	O15466 [Direct mapping] Alpha-2,8-sialyltransferase 8E Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0003828 [alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity] GO:0005515 [protein binding] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006688 [glycosphingolipid biosynthetic process] GO:0008373 [sialyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030173 [integral component of Golgi membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0097503 [sialylation] Show all	412 aa 47.7 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.