Expression of RNMT in cancer - Summary - The Human Protein Atlas

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RNMT

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RNMT
Gene description	RNA (guanine-7-) methyltransferase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA039409
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039409

GENE INFORMATION
Gene name	RNMT (HGNC Symbol)
Synonyms	RG7MT1
Description	RNA (guanine-7-) methyltransferase (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	p11.21
Chromosome location (bp)	13726660 - 13764558
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101654 (version 83.38)
Entrez gene	8731
UniProt	O43148 (UniProt - Evidence at protein level)
neXtProt	NX_O43148
Antibodypedia	RNMT antibodies

PROTEIN BROWSER

RNMT-001	RNMT-003	RNMT-005	RNMT-006	RNMT-007	RNMT-009	RNMT-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNMT-001 ENSP00000372804 ENST00000383314	O43148 [Direct mapping] mRNA cap guanine-N7 methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004482 [mRNA (guanine-N7-)-methyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005845 [mRNA cap binding complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006370 [7-methylguanosine mRNA capping] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0036265 [RNA (guanine-N7)-methylation] GO:0043235 [receptor complex] Show all	476 aa 54.8 kDa	No	0
RNMT-003 ENSP00000446426 ENST00000543302	O43148 [Direct mapping] mRNA cap guanine-N7 methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004482 [mRNA (guanine-N7-)-methyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005845 [mRNA cap binding complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006370 [7-methylguanosine mRNA capping] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0036265 [RNA (guanine-N7)-methylation] GO:0043235 [receptor complex] Show all	476 aa 54.8 kDa	No	0
RNMT-005 ENSP00000466111 ENST00000592764	O43148 [Direct mapping] mRNA cap guanine-N7 methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004482 [mRNA (guanine-N7-)-methyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005845 [mRNA cap binding complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006370 [7-methylguanosine mRNA capping] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0036265 [RNA (guanine-N7)-methylation] GO:0043235 [receptor complex] Show all	504 aa 57.7 kDa	No	0
RNMT-006 ENSP00000467475 ENST00000591746	K7EPP5 [Direct mapping] mRNA cap guanine-N7 methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		101 aa 11.1 kDa	No	0
RNMT-007 ENSP00000466252 ENST00000589866	O43148 [Direct mapping] mRNA cap guanine-N7 methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004482 [mRNA (guanine-N7-)-methyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005845 [mRNA cap binding complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006370 [7-methylguanosine mRNA capping] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0036265 [RNA (guanine-N7)-methylation] GO:0043235 [receptor complex] Show all	476 aa 54.8 kDa	No	0
RNMT-009 ENSP00000468261 ENST00000593007	K7ERH6 [Direct mapping] mRNA cap guanine-N7 methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 13 kDa	No	0
RNMT-201 ENSP00000262173 ENST00000262173	O43148 [Direct mapping] mRNA cap guanine-N7 methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004482 [mRNA (guanine-N7-)-methyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005845 [mRNA cap binding complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006370 [7-methylguanosine mRNA capping] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0036265 [RNA (guanine-N7)-methylation] GO:0043235 [receptor complex] Show all	476 aa 54.8 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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