Expression of LIPG in cancer - Summary - The Human Protein Atlas

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LIPG

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LIPG
Gene description	Lipase, endothelial
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (thyroid cancer)
HPA (cell line):	Cell line enhanced (AN3-CA, HaCaT, RPTEC TERT1, TIME)
HPA (normal tissue):	Group enriched (placenta, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Extracellular deposits and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA016966
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016966

GENE INFORMATION
Gene name	LIPG (HGNC Symbol)
Synonyms	EDL
Description	Lipase, endothelial (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	q21.1
Chromosome location (bp)	49560699 - 49599182
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101670 (version 83.38)
Entrez gene	9388
UniProt	Q9Y5X9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5X9
Antibodypedia	LIPG antibodies

PROTEIN BROWSER

LIPG-001	LIPG-002	LIPG-003	LIPG-004	LIPG-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIPG-001 ENSP00000261292 ENST00000261292	Q9Y5X9 [Direct mapping] Endothelial lipase A0A024R2B5 [Target identity:100%; Query identity:100%] Lipase, endothelial, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004465 [lipoprotein lipase activity] GO:0004620 [phospholipase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005769 [early endosome] GO:0005794 [Golgi apparatus] GO:0006629 [lipid metabolic process] GO:0007584 [response to nutrient] GO:0008201 [heparin binding] GO:0008283 [cell proliferation] GO:0008970 [phosphatidylcholine 1-acylhydrolase activity] GO:0009395 [phospholipid catabolic process] GO:0009986 [cell surface] GO:0010983 [positive regulation of high-density lipoprotein particle clearance] GO:0032376 [positive regulation of cholesterol transport] GO:0034375 [high-density lipoprotein particle remodeling] GO:0042632 [cholesterol homeostasis] GO:0043691 [reverse cholesterol transport] GO:0050746 [regulation of lipoprotein metabolic process] GO:0052689 [carboxylic ester hydrolase activity] GO:0055091 [phospholipid homeostasis] Show all	500 aa 56.8 kDa	Yes	0
LIPG-002 ENSP00000387978 ENST00000427224	B4DTR8 [Direct mapping] Endothelial lipase; cDNA FLJ57818, highly similar to Endothelial lipase (EC 3.1.1.3) Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004465 [lipoprotein lipase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006629 [lipid metabolic process] GO:0052689 [carboxylic ester hydrolase activity] Show all	426 aa 49 kDa	Yes	0
LIPG-003 ENSP00000462420 ENST00000580036	Q9Y5X9 [Direct mapping] Endothelial lipase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004465 [lipoprotein lipase activity] GO:0004620 [phospholipase activity] GO:0005615 [extracellular space] GO:0005769 [early endosome] GO:0005794 [Golgi apparatus] GO:0006629 [lipid metabolic process] GO:0008201 [heparin binding] GO:0008970 [phosphatidylcholine 1-acylhydrolase activity] GO:0009395 [phospholipid catabolic process] GO:0009986 [cell surface] GO:0010983 [positive regulation of high-density lipoprotein particle clearance] GO:0032376 [positive regulation of cholesterol transport] GO:0034375 [high-density lipoprotein particle remodeling] GO:0042632 [cholesterol homeostasis] GO:0043691 [reverse cholesterol transport] GO:0055091 [phospholipid homeostasis] Show all	354 aa 39.4 kDa	Yes	0
LIPG-004 ENSP00000463835 ENST00000577628	J3QQQ0 [Direct mapping] Endothelial lipase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004465 [lipoprotein lipase activity] GO:0005576 [extracellular region] GO:0006629 [lipid metabolic process] Show all	390 aa 43.2 kDa	No	0
LIPG-006 ENSP00000463077 ENST00000583083	J3KTN7 [Direct mapping] Endothelial lipase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0052689 [carboxylic ester hydrolase activity] Show all	24 aa 2.9 kDa	No	0

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The Human Protein Atlas

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