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MIB1

GENERAL INFORMATION

Gene name

 MIB1

Gene description

 Mindbomb E3 ubiquitin protein ligase 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in many tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA019100 , CAB037044
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA019100
CAB037044

GENE INFORMATION

Gene name

 MIB1 (HGNC Symbol)

Synonyms

 DIP-1, KIAA1323, MIB, ZZANK2, ZZZ6

Description

 Mindbomb E3 ubiquitin protein ligase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]

Chromosome

 18

Cytoband

 q11.2

Chromosome location (bp)

 21704957 - 21870957

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101752 (version 83.38)

Entrez gene

 57534

UniProt

 Q86YT6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86YT6

Antibodypedia

 MIB1 antibodies

PROTEIN BROWSER
MIB1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MIB1-001
ENSP00000261537
ENST00000261537
Q86YT6 [Direct mapping]
E3 ubiquitin-protein ligase MIB1
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001568 [blood vessel development]
GO:0001701 [in utero embryonic development]
GO:0001756 [somitogenesis]
GO:0001841 [neural tube formation]
GO:0001947 [heart looping]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0007219 [Notch signaling pathway]
GO:0007507 [heart development]
GO:0008270 [zinc ion binding]
GO:0014069 [postsynaptic density]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0031410 [cytoplasmic vesicle]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045807 [positive regulation of endocytosis]
GO:0046872 [metal ion binding]
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 1006 aa
110.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.