Expression of MXRA5 in cancer - Summary - The Human Protein Atlas

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MXRA5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MXRA5
Gene description	Matrix-remodelling associated 5
Protein class	Cancer-related genes Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, BJ hTERT+, HaCaT)
HPA (normal tissue):	Tissue enhanced (cervix, uterine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Secreted expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA000508
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable) and urothelial cancer (unfavourable).
Glioma p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000508

GENE INFORMATION
Gene name	MXRA5 (HGNC Symbol)
Synonyms	DKFZp564I1922
Description	Matrix-remodelling associated 5 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y. [provided by RefSeq, Mar 2010]
Chromosome	X
Cytoband	p22.33
Chromosome location (bp)	3308565 - 3346641
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101825 (version 83.38)
Entrez gene	25878
UniProt	Q9NR99 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NR99
Antibodypedia	MXRA5 antibodies

PROTEIN BROWSER

MXRA5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MXRA5-001 ENSP00000217939 ENST00000217939	Q9NR99 [Direct mapping] Matrix-remodeling-associated protein 5 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0008150 [biological_process] GO:0070062 [extracellular exosome] Show all	2828 aa 312.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.