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GUCY2F

GENERAL INFORMATION

Gene name

 GUCY2F

Gene description

 Guanylate cyclase 2F, retinal

Protein class

 Enzymes
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 GUCY2F (HGNC Symbol)

Synonyms

 CYGF, GC-F, GUC2DL, RetGC-2, ROS-GC2

Description

 Guanylate cyclase 2F, retinal (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]

Chromosome

 X

Cytoband

Chromosome location (bp)

 109372906 - 109482072

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101890 (version 83.38)

Entrez gene

 2986

UniProt

 P51841 (UniProt - Evidence at transcript level)

neXtProt

 NX_P51841

Antibodypedia

 GUCY2F antibodies

PROTEIN BROWSER
GUCY2F-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GUCY2F-001
ENSP00000218006
ENST00000218006
P51841 [Direct mapping]
Retinal guanylyl cyclase 2
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Enzymes
   ENZYME proteins
   Lyases
   Kinases
   RGC receptor guanylate cyclase kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
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GO:0004383 [guanylate cyclase activity]
GO:0004672 [protein kinase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005640 [nuclear outer membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0006468 [protein phosphorylation]
GO:0007168 [receptor guanylyl cyclase signaling pathway]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016020 [membrane]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0050908 [detection of light stimulus involved in visual perception]
GO:0097381 [photoreceptor disc membrane]
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 1108 aa
124.8 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.