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ATP1B4

GENERAL INFORMATION

Gene name

 ATP1B4

Gene description

 ATPase, Na+/K+ transporting, beta 4 polypeptide

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (skeletal muscle)
GTEx:Tissue enriched (skeletal muscle)
FANTOM5:Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION

Gene name

 ATP1B4

Synonyms

Description

 ATPase, Na+/K+ transporting, beta 4 polypeptide (HGNC Symbol)

Entrez gene summary

 This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Chromosome

 X

Cytoband

 q24

Chromosome location (bp)

 120362085 - 120383249

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101892 (version 83.38)

Entrez gene

 23439

UniProt

 Q9UN42 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UN42

Antibodypedia

 ATP1B4 antibodies

PROTEIN BROWSER
ATP1B4-001
ATP1B4-002
ATP1B4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP1B4-001
ENSP00000218008
ENST00000218008
Q9UN42 [Direct mapping]
Protein ATP1B4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005637 [nuclear inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010467 [gene expression]
GO:0015077 [monovalent inorganic cation transmembrane transporter activity]
GO:0015672 [monovalent inorganic cation transport]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 357 aa
41.6 kDa 		No 1
ATP1B4-002
ENSP00000355346
ENST00000361319
Q9UN42 [Direct mapping]
Protein ATP1B4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005635 [nuclear envelope]
GO:0005637 [nuclear inner membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010467 [gene expression]
GO:0015077 [monovalent inorganic cation transmembrane transporter activity]
GO:0015672 [monovalent inorganic cation transport]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 353 aa
41.1 kDa 		No 1
ATP1B4-201
ENSP00000443334
ENST00000539306
B7ZKW0 [Direct mapping]
ATP1B4 protein; Protein ATP1B4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
Show all
 314 aa
36.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.