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GLRA2

GENERAL INFORMATION

Gene name

 GLRA2

Gene description

 Glycine receptor, alpha 2

Protein class

 FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (AN3-CA)
HPA (normal tissue):Group enriched (cerebral cortex, colon, rectum)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB070422
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB070422

GENE INFORMATION

Gene name

 GLRA2 (HGNC Symbol)

Synonyms

 GLR

Description

 Glycine receptor, alpha 2 (HGNC Symbol)

Entrez gene summary

 The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 14529298 - 14731812

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101958 (version 83.38)

Entrez gene

 2742

UniProt

 P23416 (UniProt - Evidence at transcript level)

neXtProt

 NX_P23416

Antibodypedia

 GLRA2 antibodies

PROTEIN BROWSER
GLRA2-001
GLRA2-002
GLRA2-003
GLRA2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GLRA2-001
ENSP00000218075
ENST00000218075
P23416 [Direct mapping]
Glycine receptor subunit alpha-2
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007218 [neuropeptide signaling pathway]
GO:0007416 [synapse assembly]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016594 [glycine binding]
GO:0016934 [extracellular-glycine-gated chloride channel activity]
GO:0021510 [spinal cord development]
GO:0022824 [transmitter-gated ion channel activity]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043200 [response to amino acid]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:0060012 [synaptic transmission, glycinergic]
GO:1902476 [chloride transmembrane transport]
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 452 aa
52 kDa 		Yes 4
GLRA2-002
ENSP00000391606
ENST00000415367
C9JBL4 [Direct mapping]
Glycine receptor subunit alpha-2
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Predicted intracellular proteins
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GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016594 [glycine binding]
GO:0022824 [transmitter-gated ion channel activity]
GO:0034220 [ion transmembrane transport]
Show all
 215 aa
24.7 kDa 		No 0
GLRA2-003
ENSP00000347123
ENST00000355020
P23416 [Direct mapping]
Glycine receptor subunit alpha-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007218 [neuropeptide signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016594 [glycine binding]
GO:0016934 [extracellular-glycine-gated chloride channel activity]
GO:0022824 [transmitter-gated ion channel activity]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043200 [response to amino acid]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:0060012 [synaptic transmission, glycinergic]
GO:1902476 [chloride transmembrane transport]
Show all
 452 aa
52 kDa 		Yes 4
GLRA2-201
ENSP00000387756
ENST00000443437
P23416 [Direct mapping]
Glycine receptor subunit alpha-2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005230 [extracellular ligand-gated ion channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0007218 [neuropeptide signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016594 [glycine binding]
GO:0016934 [extracellular-glycine-gated chloride channel activity]
GO:0022824 [transmitter-gated ion channel activity]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0042391 [regulation of membrane potential]
GO:0043005 [neuron projection]
GO:0043200 [response to amino acid]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0050877 [neurological system process]
GO:0055085 [transmembrane transport]
GO:0060012 [synaptic transmission, glycinergic]
GO:1902476 [chloride transmembrane transport]
Show all
 363 aa
42 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.