Tissue expression of STAG2 - Summary - The Human Protein Atlas

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STAG2

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	STAG2
Gene description	Stromal antigen 2
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous nuclear expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA002857
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

N/A

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	STAG2 (HGNC Symbol)
Synonyms	SA-2, SA2, SCC3B
Description	Stromal antigen 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Chromosome	X
Cytoband	q25
Chromosome location (bp)	123960212 - 124422664
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101972 (version 83.38)
Entrez gene	10735
UniProt	Q8N3U4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N3U4
Antibodypedia	STAG2 antibodies

PROTEIN BROWSER

STAG2-001	STAG2-002	STAG2-006	STAG2-007	STAG2-008	STAG2-011	STAG2-013	STAG2-014	STAG2-017	STAG2-018	STAG2-019	STAG2-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STAG2-001 ENSP00000360199 ENST00000371157	Q8N3U4 [Direct mapping] Cohesin subunit SA-2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000785 [chromatin] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007062 [sister chromatid cohesion] GO:0007067 [mitotic nuclear division] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016925 [protein sumoylation] GO:0032876 [negative regulation of DNA endoreduplication] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045111 [intermediate filament cytoskeleton] GO:0051301 [cell division] GO:0051321 [meiotic cell cycle] Show all	1231 aa 141.3 kDa	No	0
STAG2-002 ENSP00000397265 ENST00000455404	B1AMT4 [Direct mapping] Cohesin subunit SA-2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	548 aa 62.6 kDa	No	0
STAG2-006 ENSP00000218089 ENST00000218089	Q8N3U4 [Direct mapping] Cohesin subunit SA-2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000785 [chromatin] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003682 [chromatin binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007062 [sister chromatid cohesion] GO:0007067 [mitotic nuclear division] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016925 [protein sumoylation] GO:0019827 [stem cell population maintenance] GO:0032876 [negative regulation of DNA endoreduplication] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045111 [intermediate filament cytoskeleton] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051301 [cell division] GO:0051321 [meiotic cell cycle] Show all	1268 aa 145.8 kDa	No	0
STAG2-007 ENSP00000405555 ENST00000458700	B1AMS8 [Direct mapping] Cohesin subunit SA-2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.5 kDa	No	0
STAG2-008 ENSP00000360186 ENST00000371144	Q8N3U4 [Direct mapping] Cohesin subunit SA-2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000785 [chromatin] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007062 [sister chromatid cohesion] GO:0007067 [mitotic nuclear division] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016925 [protein sumoylation] GO:0032876 [negative regulation of DNA endoreduplication] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045111 [intermediate filament cytoskeleton] GO:0051301 [cell division] GO:0051321 [meiotic cell cycle] Show all	1231 aa 141.3 kDa	No	0
STAG2-011 ENSP00000405874 ENST00000435103	B1AMT1 [Direct mapping] Cohesin subunit SA-2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		154 aa 17.2 kDa	No	0
STAG2-013 ENSP00000392118 ENST00000435215	B1AMT3 [Direct mapping] Cohesin subunit SA-2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		208 aa 23.3 kDa	No	0
STAG2-014 ENSP00000415103 ENST00000428941	B1AMT2 [Direct mapping] Cohesin subunit SA-2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		169 aa 18.8 kDa	No	0
STAG2-017 ENSP00000377988 ENST00000394478	B1AMT0 [Direct mapping] Cohesin subunit SA-2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		115 aa 12.6 kDa	No	0
STAG2-018 ENSP00000360202 ENST00000371160	Q8N3U4 [Direct mapping] Cohesin subunit SA-2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000785 [chromatin] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007062 [sister chromatid cohesion] GO:0007067 [mitotic nuclear division] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016925 [protein sumoylation] GO:0032876 [negative regulation of DNA endoreduplication] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045111 [intermediate filament cytoskeleton] GO:0051301 [cell division] GO:0051321 [meiotic cell cycle] Show all	1231 aa 141.3 kDa	No	0
STAG2-019 ENSP00000360187 ENST00000371145	Q8N3U4 [Direct mapping] Cohesin subunit SA-2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000785 [chromatin] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005730 [nucleolus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007062 [sister chromatid cohesion] GO:0007067 [mitotic nuclear division] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016925 [protein sumoylation] GO:0032876 [negative regulation of DNA endoreduplication] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045111 [intermediate filament cytoskeleton] GO:0051301 [cell division] GO:0051321 [meiotic cell cycle] Show all	1268 aa 145.8 kDa	No	0
STAG2-020 ENSP00000377987 ENST00000394477	B1AMS9 [Direct mapping] Cohesin subunit SA-2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		70 aa 7.4 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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