Expression of LUZP4 in cancer - Summary - The Human Protein Atlas

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LUZP4

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LUZP4
Gene description	Leucine zipper protein 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in a subset of cells in seminiferous ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA046436 , HPA051999
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046436	HPA051999

GENE INFORMATION
Gene name	LUZP4 (HGNC Symbol)
Synonyms	CT-8, CT28, HOM-TES-85
Description	Leucine zipper protein 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which contains two sets of heptad repeats in the N-terminus; the C-terminal most repeats form a leucine zipper domain. The presence of a leucine zipper domain suggests the protein may have DNA-binding activity and the protein has been shown to localize with a spliceosome protein (PMID: 12032826). [provided by RefSeq, Aug 2011]
Chromosome	X
Cytoband	q23
Chromosome location (bp)	115289727 - 115307556
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102021 (version 83.38)
Entrez gene	51213
UniProt	Q9P127 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P127
Antibodypedia	LUZP4 antibodies

PROTEIN BROWSER

LUZP4-001	LUZP4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LUZP4-001 ENSP00000360988 ENST00000371920	Q9P127 [Direct mapping] Leucine zipper protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003697 [single-stranded DNA binding] GO:0003727 [single-stranded RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006406 [mRNA export from nucleus] GO:0016049 [cell growth] GO:0044822 [poly(A) RNA binding] Show all	313 aa 35.9 kDa	No	0
LUZP4-002 ENSP00000360989 ENST00000371921	Q5JX98 [Direct mapping] Leucine zipper protein 4 Show all	Predicted intracellular proteins Show all		78 aa 9.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.