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KCND1

GENERAL INFORMATION

Gene name

 KCND1

Gene description

 Potassium channel, voltage gated Shal related subfamily D, member 1

Protein class

 FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous and cytoplasmic expression in several tissues, including cerebellum.

ANTIBODY IHC RELIABILITY

Data reliability
description

 External characterization data supports antibody staining.

Reliability score

 Approved based on 1 antibody.
HPA001066
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001066

GENE INFORMATION

Gene name

 KCND1 (HGNC Symbol)

Synonyms

 Kv4.1

Description

 Potassium channel, voltage gated Shal related subfamily D, member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 48961378 - 48971569

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102057 (version 83.38)

Entrez gene

 3750

UniProt

 Q9NSA2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NSA2

Antibodypedia

 KCND1 antibodies

PROTEIN BROWSER
KCND1-001
KCND1-002
KCND1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCND1-001
ENSP00000218176
ENST00000218176
Q9NSA2 [Direct mapping]
Potassium voltage-gated channel subfamily D member 1
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Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
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GO:0005216 [ion channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030425 [dendrite]
GO:0034765 [regulation of ion transmembrane transport]
GO:0043025 [neuronal cell body]
GO:0046872 [metal ion binding]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
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 647 aa
71.3 kDa 		Yes 6
KCND1-002
ENSP00000365660
ENST00000376477
Q9NSA2 [Direct mapping]
Potassium voltage-gated channel subfamily D member 1
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Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005575 [cellular_component]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016021 [integral component of membrane]
GO:0030425 [dendrite]
GO:0034765 [regulation of ion transmembrane transport]
GO:0046872 [metal ion binding]
GO:0051260 [protein homooligomerization]
GO:0071805 [potassium ion transmembrane transport]
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 270 aa
28.9 kDa 		No 1
KCND1-003
ENSP00000413989
ENST00000419374
H7C3V4 [Direct mapping]
Potassium voltage-gated channel subfamily D member 1
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Predicted intracellular proteins
Show all
GO:0005251 [delayed rectifier potassium channel activity]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016021 [integral component of membrane]
GO:0071805 [potassium ion transmembrane transport]
Show all
 133 aa
14.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.