We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancer tissues showed weak to moderate cytoplasmic positivity. Rare cases of gliomas, hepatocellular carcinomas, carcinoids, melanomas and ovarian cancers exhibited strong immunoreactivity.
A majority of the cancer cells displayed moderate cytoplasmic positivity. Several cases of ovarian, cervical and urothelial cancers as well as melanoma showed strong immunoreactivity. Many cases of lymphomas were weakly stained or negative.
GENE INFORMATION
Gene name
FMR1 (HGNC Symbol)
Synonyms
FMRP, FRAXA, MGC87458, POF, POF1
Description
Fragile X mental retardation 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010]