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SCML2

GENERAL INFORMATION

Gene name

 SCML2

Gene description

 Sex comb on midleg-like 2 (Drosophila)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in a few tissues, including testis.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA064713
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 SCML2

Synonyms

Description

 Sex comb on midleg-like 2 (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010]

Chromosome

 X

Cytoband

 p22.13

Chromosome location (bp)

 18239314 - 18354727

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102098 (version 83.38)

Entrez gene

 10389

UniProt

 Q9UQR0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQR0

Antibodypedia

 SCML2 antibodies

PROTEIN BROWSER
SCML2-001
SCML2-002
SCML2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCML2-001
ENSP00000251900
ENST00000251900
Q9UQR0 [Direct mapping]
Sex comb on midleg-like protein 2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009653 [anatomical structure morphogenesis]
GO:0031519 [PcG protein complex]
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 700 aa
77.3 kDa 		No 0
SCML2-002
ENSP00000407315
ENST00000420857
H0Y6S1 [Direct mapping]
Sex comb on midleg-like protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 125 aa
13.5 kDa 		No 0
SCML2-201
ENSP00000381126
ENST00000398048
Q9UQR0 [Direct mapping]
Sex comb on midleg-like protein 2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0009653 [anatomical structure morphogenesis]
GO:0031519 [PcG protein complex]
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 138 aa
15.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.