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PCSK1N

GENERAL INFORMATION

Gene name

 PCSK1N

Gene description

 Proprotein convertase subtilisin/kexin type 1 inhibitor

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, kidney)
GTEx:Tissue enhanced (pituitary gland)
FANTOM5:Tissue enhanced (caudate, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in endocrine cells and neuropil.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA003925 , HPA064734
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Breast
N/A
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, pituitary gland)

GENE INFORMATION

Gene name

 PCSK1N (HGNC Symbol)

Synonyms

 SAAS, SCG8, SgVIII

Description

 Proprotein convertase subtilisin/kexin type 1 inhibitor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 48831094 - 48835633

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102109 (version 83.38)

Entrez gene

 27344

UniProt

 Q9UHG2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHG2

Antibodypedia

 PCSK1N antibodies

PROTEIN BROWSER
PCSK1N-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PCSK1N-002
ENSP00000218230
ENST00000218230
Q9UHG2 [Direct mapping]
ProSAAS KEP Big SAAS Little SAAS Big PEN-LEN PEN Little LEN Big LEN
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002021 [response to dietary excess]
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005615 [extracellular space]
GO:0005802 [trans-Golgi network]
GO:0007218 [neuropeptide signaling pathway]
GO:0009409 [response to cold]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016486 [peptide hormone processing]
GO:0030141 [secretory granule]
GO:0070062 [extracellular exosome]
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 260 aa
27.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.