Expression of TIMP1 in cancer - Summary

GENERAL INFORMATION
Gene name	TIMP1
Gene description	TIMP metallopeptidase inhibitor 1
Protein class	Cancer-related genes Candidate cardiovascular disease genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in glandular cells in prostate, mucus secreting cells in cervix, salivary gland and gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 2 antibodies. HPA053417 , CAB022360
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA053417	CAB022360

GENE INFORMATION
Gene name	TIMP1 (HGNC Symbol)
Synonyms	CLGI, EPO, TIMP
Description	TIMP metallopeptidase inhibitor 1 (HGNC Symbol)
Entrez gene summary	This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p11.3
Chromosome location (bp)	47582313 - 47586789
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102265 (version 83.38)
Entrez gene	7076
UniProt	P01033 (UniProt - Evidence at protein level)
neXtProt	NX_P01033
Antibodypedia	TIMP1 antibodies

PROTEIN BROWSER

TIMP1-001	TIMP1-002	TIMP1-003	TIMP1-004	TIMP1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TIMP1-001 ENSP00000218388 ENST00000218388	P01033 [Direct mapping] Metalloproteinase inhibitor 1 Q6FGX5 [Target identity:100%; Query identity:100%] TIMP metallopeptidase inhibitor 1, isoform CRA_a; TIMP1 protein; cDNA, FLJ92204, Homo sapiens tissue inhibitor of metalloproteinase 1 (erythroidpotentiating activity, collagenase inhibitor) (TIMP1), mRNA Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001775 [cell activation] GO:0002020 [protease binding] GO:0002576 [platelet degranulation] GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0007568 [aging] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0008284 [positive regulation of cell proliferation] GO:0009725 [response to hormone] GO:0010033 [response to organic substance] GO:0010951 [negative regulation of endopeptidase activity] GO:0022617 [extracellular matrix disassembly] GO:0030168 [platelet activation] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0031093 [platelet alpha granule lumen] GO:0034097 [response to cytokine] GO:0042060 [wound healing] GO:0043066 [negative regulation of apoptotic process] GO:0043434 [response to peptide hormone] GO:0046872 [metal ion binding] GO:0048553 [negative regulation of metalloenzyme activity] GO:0051045 [negative regulation of membrane protein ectodomain proteolysis] GO:0051216 [cartilage development] GO:0070062 [extracellular exosome] GO:1901164 [negative regulation of trophoblast cell migration] GO:2001044 [regulation of integrin-mediated signaling pathway] Show all	207 aa 23.2 kDa	Yes	0
TIMP1-002 ENSP00000406671 ENST00000456754	Q5H9B5 [Direct mapping] Metalloproteinase inhibitor 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0009725 [response to hormone] GO:0010951 [negative regulation of endopeptidase activity] GO:0034097 [response to cytokine] Show all	136 aa 15.1 kDa	Yes	0
TIMP1-003 ENSP00000366216 ENST00000377017	Q5H9A7 [Direct mapping] Metalloproteinase inhibitor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0009725 [response to hormone] GO:0010951 [negative regulation of endopeptidase activity] GO:0034097 [response to cytokine] Show all	143 aa 16.1 kDa	No	0
TIMP1-004 ENSP00000405380 ENST00000441738	Q5H9B4 [Direct mapping] Metalloproteinase inhibitor 1 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0009725 [response to hormone] GO:0010951 [negative regulation of endopeptidase activity] GO:0034097 [response to cytokine] Show all	96 aa 10.7 kDa	Yes	0
TIMP1-005 ENSP00000410983 ENST00000445623	H0Y789 [Direct mapping] Metalloproteinase inhibitor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0005578 [proteinaceous extracellular matrix] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0009725 [response to hormone] GO:0010951 [negative regulation of endopeptidase activity] GO:0034097 [response to cytokine] Show all	165 aa 17.5 kDa	No	0