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PIN4

GENERAL INFORMATION

Gene name

 PIN4

Gene description

 Peptidylprolyl cis/trans isomerase, NIMA-interacting 4

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA054483
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PROGNOSTIC SUMMARY
Prognostic marker in testis cancer (favourable), urothelial cancer (favourable) and lung cancer (favourable).
Testis cancer p<0.001
Urothelial cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054483

GENE INFORMATION

Gene name

 PIN4 (HGNC Symbol)

Synonyms

 EPVH, PAR14, PAR17

Description

 Peptidylprolyl cis/trans isomerase, NIMA-interacting 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 72181353 - 72302926

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102309 (version 83.38)

Entrez gene

 5303

UniProt

 Q9Y237 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y237

Antibodypedia

 PIN4 antibodies

PROTEIN BROWSER
PIN4-001
PIN4-002
PIN4-003
PIN4-005
PIN4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIN4-001
ENSP00000362773
ENST00000373669
Q9Y237 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
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Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003677 [DNA binding]
GO:0003681 [bent DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005819 [spindle]
GO:0006364 [rRNA processing]
GO:0016853 [isomerase activity]
GO:0030684 [preribosome]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
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 156 aa
16.6 kDa 		No 0
PIN4-002
ENSP00000218432
ENST00000218432
J3KMW3 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 111 aa
11.8 kDa 		No 0
PIN4-003
ENSP00000402330
ENST00000446576
H0Y610 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 116 aa
12.4 kDa 		No 0
PIN4-005
ENSP00000421676
ENST00000496835
H0Y8P6 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 115 aa
12.2 kDa 		No 0
PIN4-201
ENSP00000409154
ENST00000423432
Q9Y237 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
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Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003677 [DNA binding]
GO:0003681 [bent DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005819 [spindle]
GO:0006364 [rRNA processing]
GO:0030684 [preribosome]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
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 133 aa
14.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.