Expression of PORCN in cancer - Summary

GENERAL INFORMATION
Gene name	PORCN
Gene description	Porcupine homolog (Drosophila)
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (LHCN-M2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, mainly in adrenal gland, CNS and seminal vesicle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA058413
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA058413

GENE INFORMATION
Gene name	PORCN (HGNC Symbol)
Synonyms	DHOF, MG61, por, PORC, PPN
Description	Porcupine homolog (Drosophila) (HGNC Symbol)
Entrez gene summary	This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	48508962 - 48520814
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102312 (version 83.38)
Entrez gene	64840
UniProt	Q9H237 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H237
Antibodypedia	PORCN antibodies

PROTEIN BROWSER

PORCN-001	PORCN-002	PORCN-008	PORCN-010	PORCN-011	PORCN-201	PORCN-202	PORCN-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PORCN-001 ENSP00000352946 ENST00000359882	Q9H237 [Direct mapping] Protein-serine O-palmitoleoyltransferase porcupine Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006497 [protein lipidation] GO:0016055 [Wnt signaling pathway] GO:0045234 [protein palmitoleylation] GO:1990698 [palmitoleoyltransferase activity] Show all	455 aa 51.6 kDa	No	8
PORCN-002 ENSP00000348233 ENST00000355961	Q9H237 [Direct mapping] Protein-serine O-palmitoleoyltransferase porcupine Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006497 [protein lipidation] GO:0016055 [Wnt signaling pathway] GO:0045234 [protein palmitoleylation] GO:1990698 [palmitoleoyltransferase activity] Show all	456 aa 51.8 kDa	No	8
PORCN-008 ENSP00000419212 ENST00000489940	C9JWI5 [Direct mapping] Protein-serine O-palmitoleoyltransferase porcupine Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	97 aa 11.2 kDa	No	2
PORCN-010 ENSP00000354978 ENST00000361988	Q9H237 [Direct mapping] Protein-serine O-palmitoleoyltransferase porcupine Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006497 [protein lipidation] GO:0016055 [Wnt signaling pathway] GO:0045234 [protein palmitoleylation] GO:1990698 [palmitoleoyltransferase activity] Show all	450 aa 51 kDa	No	8
PORCN-011 ENSP00000322304 ENST00000326194	Q9H237 [Direct mapping] Protein-serine O-palmitoleoyltransferase porcupine Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006497 [protein lipidation] GO:0009100 [glycoprotein metabolic process] GO:0016055 [Wnt signaling pathway] GO:0017147 [Wnt-protein binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0032281 [AMPA glutamate receptor complex] GO:0045234 [protein palmitoleylation] GO:0060070 [canonical Wnt signaling pathway] GO:1990698 [palmitoleoyltransferase activity] Show all	461 aa 52.3 kDa	No	8
PORCN-201 ENSP00000347207 ENST00000355092	A0A0A0MRC5 [Direct mapping] Protein-serine O-palmitoleoyltransferase porcupine Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	405 aa 45.8 kDa	No	8
PORCN-202 ENSP00000356546 ENST00000367574	Q9H237 [Direct mapping] Protein-serine O-palmitoleoyltransferase porcupine Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006497 [protein lipidation] GO:0016055 [Wnt signaling pathway] GO:0045234 [protein palmitoleylation] GO:1990698 [palmitoleoyltransferase activity] Show all	455 aa 51.6 kDa	No	9
PORCN-203 ENSP00000446401 ENST00000537758	Q9H237 [Direct mapping] Protein-serine O-palmitoleoyltransferase porcupine Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006497 [protein lipidation] GO:0016055 [Wnt signaling pathway] GO:0045234 [protein palmitoleylation] GO:1990698 [palmitoleoyltransferase activity] Show all	456 aa 51.8 kDa	No	9