Expression of ITIH6 in cancer - Summary - The Human Protein Atlas

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ITIH6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ITIH6
Gene description	Inter-alpha-trypsin inhibitor heavy chain family, member 6
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (melanoma)
HPA (cell line):	Cell line enriched (WM-115)
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA000506
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000506

GENE INFORMATION
Gene name	ITIH6 (HGNC Symbol)
Synonyms	ITIH5L, UNQ6369
Description	Inter-alpha-trypsin inhibitor heavy chain family, member 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the interalpha trypsin inhibitor heavy chain (ITIH) family. Interalpha trypsin inhibitor (ITI) is composed of two heavy chains (containing VWA domain) and one light chain. The light chain confers the protease-inhibitor function, while the heavy chains are involved in mediating protein-protein interactions with the components of the extracellular matrix. [provided by RefSeq, Sep 2009]
Chromosome	X
Cytoband	p11.22
Chromosome location (bp)	54748899 - 54798240
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102313 (version 83.38)
Entrez gene	347365
UniProt	Q6UXX5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6UXX5
Antibodypedia	ITIH6 antibodies

PROTEIN BROWSER

ITIH6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITIH6-001 ENSP00000218436 ENST00000218436	Q6UXX5 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H6 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] Show all	1313 aa 143.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.