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SRPX2

GENERAL INFORMATION

Gene name

 SRPX2

Gene description

 Sushi-repeat containing protein, X-linked 2

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, HUVEC TERT2)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA038786
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA038786

GENE INFORMATION

Gene name

 SRPX2 (HGNC Symbol)

Synonyms

 SRPUL

Description

 Sushi-repeat containing protein, X-linked 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and mental retardation. [provided by RefSeq, May 2010]

Chromosome

 X

Cytoband

 q22.1

Chromosome location (bp)

 100644218 - 100671299

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102359 (version 83.38)

Entrez gene

 27286

UniProt

 O60687 (UniProt - Evidence at protein level)

neXtProt

 NX_O60687

Antibodypedia

 SRPX2 antibodies

PROTEIN BROWSER
SRPX2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRPX2-001
ENSP00000362095
ENST00000373004
O60687 [Direct mapping]
Sushi repeat-containing protein SRPX2
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0009986 [cell surface]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030054 [cell junction]
GO:0036458 [hepatocyte growth factor binding]
GO:0042325 [regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0048870 [cell motility]
GO:0051965 [positive regulation of synapse assembly]
GO:0060076 [excitatory synapse]
GO:0071625 [vocalization behavior]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0097060 [synaptic membrane]
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 465 aa
53 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.