Expression of ARMCX3 in cancer - Summary - The Human Protein Atlas

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ARMCX3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARMCX3
Gene description	Armadillo repeat containing, X-linked 3
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA000325 , HPA000967
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000325	HPA000967

GENE INFORMATION
Gene name	ARMCX3 (HGNC Symbol)
Synonyms	ALEX3, GASP6
Description	Armadillo repeat containing, X-linked 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q22.1
Chromosome location (bp)	101622797 - 101627843
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102401 (version 83.38)
Entrez gene	51566
UniProt	Q9UH62 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UH62
Antibodypedia	ARMCX3 antibodies

PROTEIN BROWSER

ARMCX3-001	ARMCX3-003	ARMCX3-004	ARMCX3-006	ARMCX3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARMCX3-001 ENSP00000340672 ENST00000341189	Q9UH62 [Direct mapping] Armadillo repeat-containing X-linked protein 3 A0A024RCF9 [Target identity:100%; Query identity:100%] Armadillo repeat containing, X-linked 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0031307 [integral component of mitochondrial outer membrane] GO:0034613 [cellular protein localization] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	379 aa 42.5 kDa	No	1
ARMCX3-003 ENSP00000454251 ENST00000479298	H3BM63 [Direct mapping] Armadillo repeat-containing X-linked protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	63 aa 6.8 kDa	No	1
ARMCX3-004 ENSP00000454483 ENST00000471229	Q9UH62 [Direct mapping] Armadillo repeat-containing X-linked protein 3 A0A024RCF9 [Target identity:100%; Query identity:100%] Armadillo repeat containing, X-linked 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] Show all	379 aa 42.5 kDa	No	1
ARMCX3-006 ENSP00000457997 ENST00000491568	H3BV87 [Direct mapping] Armadillo repeat-containing X-linked protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	94 aa 10.2 kDa	No	1
ARMCX3-201 ENSP00000439032 ENST00000537169	Q9UH62 [Direct mapping] Armadillo repeat-containing X-linked protein 3 A0A024RCF9 [Target identity:100%; Query identity:100%] Armadillo repeat containing, X-linked 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] Show all	379 aa 42.5 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.