Expression of NALCN in cancer - Summary - The Human Protein Atlas

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NALCN

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NALCN
Gene description	Sodium leak channel, non selective
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HaCaT, TIME, U-87 MG)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tisssues, most abundant in neuronal processes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA031889 , HPA031890 , HPA031958
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031889	HPA031890	HPA031958

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Several cases of ymphomas along with a few cases of melanomas and hepatocellular carcinomas displayed weak to moderate cytoplasmic staining. Other cancer tissues were mainly negative.

GENE INFORMATION
Gene name	NALCN (HGNC Symbol)
Synonyms	bA430M15.1, CanIon, VGCNL1
Description	Sodium leak channel, non selective (HGNC Symbol)
Entrez gene summary	NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008]
Chromosome	13
Cytoband
Chromosome location (bp)	101053776 - 101416492
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102452 (version 83.38)
Entrez gene	259232
UniProt	Q8IZF0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZF0
Antibodypedia	NALCN antibodies

PROTEIN BROWSER

NALCN-001	NALCN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NALCN-001 ENSP00000251127 ENST00000251127	Q8IZF0 [Direct mapping] Sodium leak channel non-selective protein A0A024RE05 [Target identity:100%; Query identity:100%] Voltage gated channel like 1, isoform CRA_a Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005272 [sodium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	1738 aa 200.3 kDa	No	>9
NALCN-201 ENSP00000365373 ENST00000376200	Q8IZF0 [Direct mapping] Sodium leak channel non-selective protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005272 [sodium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	218 aa 25.4 kDa	No	4

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.