Expression of TNFSF13B in cancer - Summary - The Human Protein Atlas

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TNFSF13B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TNFSF13B
Gene description	Tumor necrosis factor (ligand) superfamily, member 13b
Protein class	Cancer-related genes CD markers FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (U-937)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, most abundant in subsets of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB009188
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB009188

GENE INFORMATION
Gene name	TNFSF13B (HGNC Symbol)
Synonyms	BAFF, BLYS, CD257, TALL-1, TALL1, THANK, TNFSF20
Description	Tumor necrosis factor (ligand) superfamily, member 13b (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Chromosome	13
Cytoband	q33.3
Chromosome location (bp)	108251240 - 108308484
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102524 (version 83.38)
Entrez gene	10673
UniProt	Q9Y275 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y275
Antibodypedia	TNFSF13B antibodies

PROTEIN BROWSER

TNFSF13B-001	TNFSF13B-201	TNFSF13B-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNFSF13B-001 ENSP00000365048 ENST00000375887	Q9Y275 [Direct mapping] Tumor necrosis factor ligand superfamily member 13B Tumor necrosis factor ligand superfamily member 13b, membrane form Tumor necrosis factor ligand superfamily member 13b, soluble form Show all	CD markers MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001782 [B cell homeostasis] GO:0002636 [positive regulation of germinal center formation] GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030890 [positive regulation of B cell proliferation] GO:0031295 [T cell costimulation] GO:0031296 [B cell costimulation] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042102 [positive regulation of T cell proliferation] GO:0048305 [immunoglobulin secretion] GO:0048471 [perinuclear region of cytoplasm] GO:0050776 [regulation of immune response] Show all	285 aa 31.2 kDa	No	0
TNFSF13B-201 ENSP00000389540 ENST00000430559	Q9Y275 [Direct mapping] Tumor necrosis factor ligand superfamily member 13B Tumor necrosis factor ligand superfamily member 13b, membrane form Tumor necrosis factor ligand superfamily member 13b, soluble form Show all	CD markers MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0048471 [perinuclear region of cytoplasm] Show all	266 aa 29.1 kDa	No	0
TNFSF13B-202 ENSP00000445334 ENST00000542136	Q9Y275 [Direct mapping] Tumor necrosis factor ligand superfamily member 13B Tumor necrosis factor ligand superfamily member 13b, membrane form Tumor necrosis factor ligand superfamily member 13b, soluble form Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0048471 [perinuclear region of cytoplasm] Show all	164 aa 17.6 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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