Fields »
ABOUT
HELP
BLOG
KLF5

GENERAL INFORMATION

Gene name

 KLF5

Gene description

 Kruppel-like factor 5 (intestinal)

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HaCaT, hTCEpi, RT4, SiHa)
HPA (normal tissue):Tissue enhanced (skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA040398
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040398

GENE INFORMATION

Gene name

 KLF5 (HGNC Symbol)

Synonyms

 BTEB2, CKLF, IKLF

Description

 Kruppel-like factor 5 (intestinal) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Chromosome

 13

Cytoband

 q22.1

Chromosome location (bp)

 73054976 - 73077542

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102554 (version 83.38)

Entrez gene

 688

UniProt

 Q13887 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13887

Antibodypedia

 KLF5 antibodies

PROTEIN BROWSER
KLF5-001
KLF5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLF5-001
ENSP00000366915
ENST00000377687
Q13887 [Direct mapping]
Krueppel-like factor 5
Q5T6X2 [Target identity:100%; Query identity:100%]
Kruppel-like factor 5 (Intestinal); Kruppel-like factor 5 (Intestinal), isoform CRA_a
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001525 [angiogenesis]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0030033 [microvillus assembly]
GO:0032534 [regulation of microvillus assembly]
GO:0035914 [skeletal muscle cell differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0060576 [intestinal epithelial cell development]
Show all
 457 aa
50.8 kDa 		No 0
KLF5-201
ENSP00000440407
ENST00000539231
Q13887 [Direct mapping]
Krueppel-like factor 5
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 366 aa
41.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.