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STK24

GENERAL INFORMATION

Gene name

 STK24

Gene description

 Serine/threonine kinase 24

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA026435 , HPA026502
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable), renal cancer (favourable) and pancreatic cancer (unfavourable).
Lung cancer p<0.001
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA026435
HPA026502

GENE INFORMATION

Gene name

 STK24 (HGNC Symbol)

Synonyms

 MST-3, MST3, MST3B, STE20, STK3

Description

 Serine/threonine kinase 24 (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Chromosome

 13

Cytoband

 q32.2

Chromosome location (bp)

 98445185 - 98577940

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102572 (version 83.38)

Entrez gene

 8428

UniProt

 Q9Y6E0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6E0

Antibodypedia

 STK24 antibodies

PROTEIN BROWSER
STK24-001
STK24-002
STK24-003
STK24-005
STK24-006
STK24-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STK24-001
ENSP00000442539
ENST00000539966
Q9Y6E0 [Direct mapping]
Serine/threonine-protein kinase 24 Serine/threonine-protein kinase 24 36 kDa subunit Serine/threonine-protein kinase 24 12 kDa subunit
Q5U0E6 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 95; Serine/threonine kinase 24 (STE20 homolog, yeast); Serine/threonine kinase 24 (STE20 homolog, yeast), isoform CRA_c
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030336 [negative regulation of cell migration]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042542 [response to hydrogen peroxide]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048679 [regulation of axon regeneration]
GO:0070062 [extracellular exosome]
GO:0097194 [execution phase of apoptosis]
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 431 aa
47.9 kDa 		No 0
STK24-002
ENSP00000365730
ENST00000376547
Q9Y6E0 [Direct mapping]
Serine/threonine-protein kinase 24 Serine/threonine-protein kinase 24 36 kDa subunit Serine/threonine-protein kinase 24 12 kDa subunit
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030336 [negative regulation of cell migration]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042542 [response to hydrogen peroxide]
GO:0042981 [regulation of apoptotic process]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048679 [regulation of axon regeneration]
GO:0070062 [extracellular exosome]
GO:0097194 [execution phase of apoptosis]
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 443 aa
49.3 kDa 		No 0
STK24-003
ENSP00000402764
ENST00000444574
H0Y630 [Direct mapping]
Serine/threonine-protein kinase 24
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
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 369 aa
40.8 kDa 		No 0
STK24-005
ENSP00000365737
ENST00000376554
Q5JV98 [Direct mapping]
Serine/threonine-protein kinase 24
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
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 209 aa
23.1 kDa 		No 0
STK24-006
ENSP00000402810
ENST00000418038
Q5JV99 [Direct mapping]
Serine/threonine-protein kinase 24
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
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 142 aa
15.8 kDa 		No 0
STK24-201
ENSP00000380651
ENST00000397517
B4DR80 [Direct mapping]
Serine/threonine-protein kinase 24; cDNA FLJ61159, highly similar to Serine/threonine-protein kinase 24 (EC 2.7.11.1)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 412 aa
45.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.