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ACP5
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ACP5

Gene description

Acid phosphatase 5, tartrate resistant

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (lung)
GTEx:Tissue enhanced (lung)
FANTOM5:Tissue enhanced (adipose tissue, lung)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in macrophages in lung.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 3 antibodies.
HPA057655 , HPA059463 , CAB002584
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, lung)

GENE INFORMATION

Gene name

ACP5 (HGNC Symbol)

Synonyms

HPAP, TRAP

Description

Acid phosphatase 5, tartrate resistant (HGNC Symbol)

Entrez gene summary

This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

11574660 - 11579008

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102575 (version 83.38)

Entrez gene

54

UniProt

P13686 (UniProt - Evidence at protein level)

neXtProt

NX_P13686

Antibodypedia

ACP5 antibodies

PROTEIN BROWSER

ACP5-001
ACP5-002
ACP5-003
ACP5-006
ACP5-007
ACP5-008
ACP5-009
ACP5-011
ACP5-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACP5-001
ENSP00000392374
ENST00000412435
P13686 [Direct mapping]
Tartrate-resistant acid phosphatase type 5
A0A024R7F8 [Target identity:100%; Query identity:100%]
Acid phosphatase 5, tartrate resistant, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006771 [riboflavin metabolic process]
GO:0008198 [ferrous iron binding]
GO:0008199 [ferric iron binding]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
325 aa
36.6 kDa
Yes 0
ACP5-002
ENSP00000218758
ENST00000218758
P13686 [Direct mapping]
Tartrate-resistant acid phosphatase type 5
A0A024R7F8 [Target identity:100%; Query identity:100%]
Acid phosphatase 5, tartrate resistant, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006771 [riboflavin metabolic process]
GO:0008198 [ferrous iron binding]
GO:0008199 [ferric iron binding]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
325 aa
36.6 kDa
Yes 0
ACP5-003
ENSP00000468767
ENST00000592828
P13686 [Direct mapping]
Tartrate-resistant acid phosphatase type 5
A0A024R7F8 [Target identity:100%; Query identity:100%]
Acid phosphatase 5, tartrate resistant, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0003993 [acid phosphatase activity]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006771 [riboflavin metabolic process]
GO:0007162 [negative regulation of cell adhesion]
GO:0008198 [ferrous iron binding]
GO:0008199 [ferric iron binding]
GO:0010043 [response to zinc ion]
GO:0014070 [response to organic cyclic compound]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0030316 [osteoclast differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0032496 [response to lipopolysaccharide]
GO:0032691 [negative regulation of interleukin-1 beta production]
GO:0032695 [negative regulation of interleukin-12 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032929 [negative regulation of superoxide anion generation]
GO:0033555 [multicellular organismal response to stress]
GO:0033591 [response to L-ascorbic acid]
GO:0034097 [response to cytokine]
GO:0044281 [small molecule metabolic process]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045453 [bone resorption]
GO:0050728 [negative regulation of inflammatory response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0060349 [bone morphogenesis]
GO:0070062 [extracellular exosome]
GO:0070723 [response to cholesterol]
Show all
325 aa
36.6 kDa
Yes 0
ACP5-006
ENSP00000413456
ENST00000433365
P13686 [Direct mapping]
Tartrate-resistant acid phosphatase type 5
A0A024R7F8 [Target identity:100%; Query identity:100%]
Acid phosphatase 5, tartrate resistant, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006771 [riboflavin metabolic process]
GO:0008198 [ferrous iron binding]
GO:0008199 [ferric iron binding]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
325 aa
36.6 kDa
Yes 0
ACP5-007
ENSP00000464831
ENST00000591319
K7EIP0 [Direct mapping]
Tartrate-resistant acid phosphatase type 5
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
52 aa
5.5 kDa
Yes 0
ACP5-008
ENSP00000465498
ENST00000592659
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
6 aa
0.8 kDa
No 0
ACP5-009
ENSP00000468685
ENST00000589792
K7ESF2 [Direct mapping]
Tartrate-resistant acid phosphatase type 5
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
74 aa
8 kDa
Yes 0
ACP5-011
ENSP00000465127
ENST00000590832
K7EJD9 [Direct mapping]
Tartrate-resistant acid phosphatase type 5
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
124 aa
13.7 kDa
Yes 0
ACP5-012
ENSP00000468509
ENST00000590420
K7ES19 [Direct mapping]
Tartrate-resistant acid phosphatase type 5
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
59 aa
6.5 kDa
Yes 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.