Tissue expression of ACP5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ACP5
Gene description	Acid phosphatase 5, tartrate resistant
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lung)
GTEx:	Tissue enhanced (lung)
FANTOM5:	Tissue enhanced (adipose tissue, lung)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in macrophages in lung.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 3 antibodies. HPA057655 , HPA059463 , CAB002584
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue, lung)

GENE INFORMATION
Gene name	ACP5 (HGNC Symbol)
Synonyms	HPAP, TRAP
Description	Acid phosphatase 5, tartrate resistant (HGNC Symbol)
Entrez gene summary	This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	11574660 - 11579008
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102575 (version 83.38)
Entrez gene	54
UniProt	P13686 (UniProt - Evidence at protein level)
neXtProt	NX_P13686
Antibodypedia	ACP5 antibodies

PROTEIN BROWSER

ACP5-001	ACP5-002	ACP5-003	ACP5-006	ACP5-007	ACP5-008	ACP5-009	ACP5-011	ACP5-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACP5-001 ENSP00000392374 ENST00000412435	P13686 [Direct mapping] Tartrate-resistant acid phosphatase type 5 A0A024R7F8 [Target identity:100%; Query identity:100%] Acid phosphatase 5, tartrate resistant, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0008198 [ferrous iron binding] GO:0008199 [ferric iron binding] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	325 aa 36.6 kDa	Yes	0
ACP5-002 ENSP00000218758 ENST00000218758	P13686 [Direct mapping] Tartrate-resistant acid phosphatase type 5 A0A024R7F8 [Target identity:100%; Query identity:100%] Acid phosphatase 5, tartrate resistant, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0008198 [ferrous iron binding] GO:0008199 [ferric iron binding] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	325 aa 36.6 kDa	Yes	0
ACP5-003 ENSP00000468767 ENST00000592828	P13686 [Direct mapping] Tartrate-resistant acid phosphatase type 5 A0A024R7F8 [Target identity:100%; Query identity:100%] Acid phosphatase 5, tartrate resistant, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0003993 [acid phosphatase activity] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0007162 [negative regulation of cell adhesion] GO:0008198 [ferrous iron binding] GO:0008199 [ferric iron binding] GO:0010043 [response to zinc ion] GO:0014070 [response to organic cyclic compound] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016787 [hydrolase activity] GO:0030316 [osteoclast differentiation] GO:0030335 [positive regulation of cell migration] GO:0032496 [response to lipopolysaccharide] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032695 [negative regulation of interleukin-12 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0032929 [negative regulation of superoxide anion generation] GO:0033555 [multicellular organismal response to stress] GO:0033591 [response to L-ascorbic acid] GO:0034097 [response to cytokine] GO:0044281 [small molecule metabolic process] GO:0045019 [negative regulation of nitric oxide biosynthetic process] GO:0045453 [bone resorption] GO:0050728 [negative regulation of inflammatory response] GO:0050830 [defense response to Gram-positive bacterium] GO:0060349 [bone morphogenesis] GO:0070062 [extracellular exosome] GO:0070723 [response to cholesterol] Show all	325 aa 36.6 kDa	Yes	0
ACP5-006 ENSP00000413456 ENST00000433365	P13686 [Direct mapping] Tartrate-resistant acid phosphatase type 5 A0A024R7F8 [Target identity:100%; Query identity:100%] Acid phosphatase 5, tartrate resistant, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0008198 [ferrous iron binding] GO:0008199 [ferric iron binding] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	325 aa 36.6 kDa	Yes	0
ACP5-007 ENSP00000464831 ENST00000591319	K7EIP0 [Direct mapping] Tartrate-resistant acid phosphatase type 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 5.5 kDa	Yes	0
ACP5-008 ENSP00000465498 ENST00000592659		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		6 aa 0.8 kDa	No	0
ACP5-009 ENSP00000468685 ENST00000589792	K7ESF2 [Direct mapping] Tartrate-resistant acid phosphatase type 5 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 8 kDa	Yes	0
ACP5-011 ENSP00000465127 ENST00000590832	K7EJD9 [Direct mapping] Tartrate-resistant acid phosphatase type 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	124 aa 13.7 kDa	Yes	0
ACP5-012 ENSP00000468509 ENST00000590420	K7ES19 [Direct mapping] Tartrate-resistant acid phosphatase type 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.5 kDa	Yes	0